Autoxidative Carbon-Carbon Bond Formation from Carbon-Hydrogen Bonds
Autoxidative Carbon-Carbon Bond Formation from Carbon-Hydrogen Bonds
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DOI：
10.1002/anie.201000711
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发表时间：
2010-01-01
影响因子：
16.6
通讯作者：
Klussmann, Martin
中科院分区：
文献类型：
--
作者：
Pinter, Aron;Sud, Abhishek;Klussmann, Martin
只有氧气和酸！在没有溶剂的环境条件下，只需使用氧气和催化量的甲磺酸，就可以实现杂蒽和其他活性苯基化合物与碳亲核试剂（如酮类）的氧化偶联。提出的反应机制包括通过形成氢过氧化物激活底物；因此，该方法可视为一种“自氧化偶联反应”。
Only oxygen and acid! The oxidative coupling of xanthene and other activated benzylic compounds with carbon nucleophiles such as ketones, can be performed under ambient conditions without solvent by simply using oxygen and catalytic amounts of methanesulfonic acid. The proposed reaction mechanism involves substrate activation by formation of hydroperoxides; the method can therefore be regarded as an “autoxidative coupling reaction”.