The maternal ventralizing locus torpedo is allelic to faint little ball, an embryonic lethal, and encodes the Drosophila EGF receptor homolog.
The maternal ventralizing locus torpedo is allelic to faint little ball, an embryonic lethal, and encodes the Drosophila EGF receptor homolog.
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母体腹侧位点鱼雷与微弱的小球（胚胎致死性）等位，编码果蝇 EGF 受体同源物。
DOI：
10.1016/0092-8674(89)90641-7
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发表时间：
1989
期刊：
影响因子：
64.5
通讯作者：
Schüpbach,T
中科院分区：
文献类型：
--
作者：
Price,JV;Clifford,RJ;Schüpbach,T
黑腹果蝇的鱼雷基因参与了卵壳和胚胎背腹型的形成。我们分离出了鱼雷的新等位基因，并发现鱼雷与合子胚胎致死性微弱提升/e球等位。我们已经表明，鱼雷居住在细分57 F的第二染色体上，在相同的位置作为果蝇同源的表皮生长因子受体（DER）。使用包含大部分DER编码区的粘粒作为杂交探针，我们已经证明，消除鱼雷活性的细胞学上的小缺陷也会去除DER基因，并且作为强鱼雷等位基因分离的倒位会破坏编码区DER基因。我们认为鱼雷是DER基因。
The torpedo gene of Drosophila melanogaster is involved in the establishment of the dorsoventral pattern of eggshell and embryo. We have isolated new alleles of torpedo and have found that torpedo is allelic to the zygotic embryonic lethal faint lift/e ball. We have shown that torpedo resides in subdivision 57F on the second chromosome-at the same location as the Drosophila homolog of the EGF receptor (DER). Using a cosmid that contains most of the DER coding region as a hybridization probe, we have shown that a cytologically small deficiency that eliminates torpedo activity also removes the DER gene, and that an inversion that was isolated as a strong torpedo allele breaks the coding region of the DER gene. We conclude that torpedo is the DER gene.