Fluoroquinolone enhances the mutation frequency for meropenem-selected carbapenem resistance in Pseudomonas aeruginosa, but use of the high-potency drug doripenem inhibits mutant formation
Fluoroquinolone enhances the mutation frequency for meropenem-selected carbapenem resistance in Pseudomonas aeruginosa, but use of the high-potency drug doripenem inhibits mutant formation
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DOI：
10.1128/aac.00464-08
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发表时间：
2008-10-01
影响因子：
4.9
通讯作者：
Ike, Yasuyoshi
中科院分区：
文献类型：
--
作者：
Tanimoto, Koichi;Tomita, Haruyoshi;Ike, Yasuyoshi
在使用碳青霉烯类抗生素筛选的铜绿假单胞菌菌株中，在存在亚抑制浓度氟喹诺酮类药物的情况下，碳青霉烯类抗生素耐药突变频率增加。突变体显示OprD活性的丧失或mexAB-oprM表达的增加。通过美罗培南选择获得最高的突变体分离频率，而多利培南抑制突变体生长。
The mutation frequency for carbapenem resistance in Pseudomonas aeruginosa strains that were selected with carbapenems was enhanced in the presence of subinhibitory concentrations of fluoroquinolones. The mutants showed either a loss of OprD activity or increased mexAB-oprM expression. The highest mutant isolation frequency was obtained by selection with meropenem, while doripenem inhibited mutant growth.