Medium-chain triglyceride diet stimulates less GIP secretion and suppresses body weight and fat mass gain compared with long-chain triglyceride diet
Medium-chain triglyceride diet stimulates less GIP secretion and suppresses body weight and fat mass gain compared with long-chain triglyceride diet
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DOI：
10.1152/ajpendo.00200.2018
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发表时间：
2019-07-01
影响因子：
5.1
通讯作者：
Inagaki, Nobuya
中科院分区：
文献类型：
--
作者：
Murata, Yuki;Harada, Norio;Inagaki, Nobuya
胃抑制多肽（GIP）是由肠内分泌K细胞分泌的肠促胰岛素，并增强胰腺β细胞的胰岛素分泌。GIP还增强长链甘油三酯（LCT）饮食诱导的肥胖和胰岛素抵抗。已知长期摄入中链甘油三酯（MCI）饮食比LCT饮食诱导更少的体重和脂肪量增加。然而，MCT饲料喂养对GIP分泌的影响以及MCT饲料喂养条件下GIP对体重和脂肪量的影响尚不清楚。本研究我们评估了单次给予MCI油对GIP分泌的影响，并比较了长期MCT和LCT饮食对野生型（WT）和GIP敲除（GIP KO）小鼠体重和脂肪量增加的影响。在WT小鼠中，LCT油单次给药诱导GIP分泌，但MCT油未诱导。与对照脂肪（CF）饮食相比，WT小鼠长期摄入LCT饮食诱导GIP分泌过多，体重和脂肪量显著增加。相反。MCT饲料未诱导GIP分泌过多。与CF饲料喂养的小鼠相比，MCT饲料喂养的小鼠显示出较小的体重增加和脂肪量增加。在GIP KO小鼠中，LCT饲料喂养小鼠的体重和脂肪量显著减轻，但MCT饲料喂养小鼠的体重和脂肪量未显著减轻。我们的研究结果表明，长期摄入MCT饮食刺激较少的GIP分泌和抑制体重和脂肪量增加相比，LCT饮食。
Gastric inhibitory polypeptide (GIP) is an incretin secreted from enteroendocrine K cells and potentiates insulin secretion from pancreatic beta-cells. GIP also enhances long-chain triglyceride (LCT) diet-induced obesity and insulin resistance. Long-term intake of medium-chain triglyceride (MCI) diet is known to induce less body weight and fat mass gain than that of LCT diet. However, the effect of MCT diet feeding on GIP secretion and the effect of GIP on body weight and fat mass under MCT diet-feeding condition are unknown. In this study. we evaluated the effect of single MCI oil administration on GIP secretion and compared the effect of long-term MCT and LCT diet on body weight and fat mass gain in wild-type (WT) and GIP-knockout (GIP KO) mice. Single administration of LCT oil induced GIP secretion but that of MCT oil did not in WT mice. Long-term intake of LCT diet induced GIP hypersecretion and significant body weight and fat mass gain compared with that of control fat (CF) diet in WT mice. In contrast. MCT diet did not induce GIP hypersecretion. and MCT diet-fed mice showed smaller increase in body weight and fat mass gain compared with CF diet-fed mice. In GIP KO mice, body weight and fat mass were markedly attenuated in LCT diet-fed mice but not in MCT diet-fed mice. Our results suggest that long-term intake of MCT diet stimulates less GIP secretion and suppresses body weight and fat mass gain compared with that of LCT diet.