Differential attention-dependent response modulation across cell classes in macaque visual area V4
Differential attention-dependent response modulation across cell classes in macaque visual area V4
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DOI：
10.1016/j.neuron.2007.06.018
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发表时间：
2007-07-05
期刊：
影响因子：
16.2
通讯作者：
Reynolds, John H.
中科院分区：
文献类型：
--
作者：
Mitchell, Jude F.;Sundberg, Kristy A.;Reynolds, John H.
皮层包含多种细胞类型，但注意力研究并未区分它们，这限制了对将注意力反馈转化为改进的视觉处理的局部回路的理解。表达小白蛋白的抑制性中间神经元可以根据其较短的动作电位持续时间与锥体神经元区分开来。当猴子执行一项需要注意力的任务时，我们记录了 V4 区的神经元。我们发现动作电位持续时间的分布是强烈双峰的。与具有宽动作电位的神经元相比，具有窄动作电位的神经元具有更高的放电率和更大的注意力依赖性绝对放电率增加。两个班级的响应增加百分比相似。我们还发现证据表明注意力可以提高神经元反应的可靠性。这种调节在假定的中间神经元中强两倍多。这些发现得出了令人惊讶的结论：最强的注意力调节发生在不在区域之间传输信号的局部中间神经元中。
The cortex contains multiple cell types, but studies of attention have not distinguished between them, limiting understanding of the local circuits that transform attentional feedback into improved visual processing. Parvalbumin-expressing inhibitory interneurons can be distinguished from pyramidal neurons based on their briefer action potential durations. We recorded neurons in area V4 as monkeys performed an attention-demanding task. We find that the distribution of action potential durations is strongly bimodal. Neurons with narrow action potentials have higher firing rates and larger attention-dependent increases in absolute firing rate than neurons with broad action potentials. The percentage increase in response is similar across the two classes. We also find evidence that attention increases the reliability of the neuronal response. This modulation is more than twofold stronger among putative interneurons. These findings lead to the surprising conclusion that the strongest attentional modulation occurs among local interneurons that do not transmit signals between areas.