CART peptide 55-102 microinjected into the nucleus accumbens inhibits the expression of behavioral sensitization by amphetamine
CART peptide 55-102 microinjected into the nucleus accumbens inhibits the expression of behavioral sensitization by amphetamine
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DOI：
10.1016/j.regpep.2007.07.003
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发表时间：
2007-12-04
影响因子：
--
通讯作者：
Kim, Jeong-Hoon
中科院分区：
文献类型：
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作者：
Kim, Seungwoo;Yoon, Hyung Shin;Kim, Jeong-Hoon
CART肽已被证明可以调节精神运动兴奋剂的行为。在这里，我们进一步研究了伏隔核具有生物活性的CART 55-102肽(NAcc)在苯丙胺(Amph)行为敏化表达中的作用。大鼠预先给予生理盐水或安非他明(1 mg/kg，ip)5次。停药2周后，在NACE内注射生理盐水或CART 55-102(1.0mg2.5mg0.5亩L/侧)，然后给予AMPH攻击(1 mg/kg，ip)。向CART 55-102肽的NAcc内微量注射Amph可剂量依赖性地抑制重复AMPH预暴露所引起的运动和站立能力的增强。这些结果表明，NAcc中的CART 55-102肽对AMPH行为敏化的表达具有代偿性抑制作用，并进一步提示CART肽可能是控制精神运动兴奋剂药物成瘾的有用靶点。(C)2007 Elsevier B.V.保留所有权利。
CART peptide has been shown to regulate the actions of psychomotor stimulants. Here we have further investigated the role of the biologically active CART 55-102 peptide in the nucleus accumbens (NAcc) in the expression of behavioral sensitization by amphetamine (AMPH). Rats were pre-exposed 5 times to either saline or AMPH (1 mg/kg, i.p.). After 2 weeks of withdrawal, rats were microinjected into the NAce with saline or CART 55-102 (1.0, or 2.5 mu g/0.5 mu l/side) followed by AMPH challenge (1 mg/kg, i.p.). The enhanced increase of locomotion and rearing produced by repeated AMPH pre-exposures was dose-dependently inhibited by microinjection into the NAcc of CART 55-102 peptide. These results indicate that CART 55-102 peptide in the NAcc can play a compensatory inhibitory role in the expression of behavioral sensitization by AMPH and further suggest that CART peptide may be a useful target to control the drug addiction by psychomotor stimulants. (c) 2007 Elsevier B.V. All rights reserved.