Study of white matter at the centrum semiovale level with magnetic resonance spectroscopy and diffusion tensor imaging in cerebral small vessel disease.
Study of white matter at the centrum semiovale level with magnetic resonance spectroscopy and diffusion tensor imaging in cerebral small vessel disease.
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DOI：
10.4238/2014.april.8.11
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发表时间：
2014-04
期刊：
影响因子：
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通讯作者：
L. Huang;Xueying Ling;C. Li;S. Zhang;G. B. Chi;Anding Xu
中科院分区：
文献类型：
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作者：
L. Huang;Xueying Ling;C. Li;S. Zhang;G. B. Chi;Anding Xu
白色病变（WML）是脑小血管病（SVD）患者常见的MRI表现，但其病理机制尚不清楚。我们观察了SVD患者白色物质的代谢和显微解剖。对12例临床诊断为SVD的患者和6例正常对照者进行磁共振波谱（MRS）和弥散张量成像（DTI）检查。选择半卵圆中心水平的白色物质作为感兴趣区域（ROI）。MRS检测脑内N-乙酰-L-天冬氨酸（NAA）、肌酸（Cr）、胆碱（Cho）等代谢参数，DTI检测脑内平均弥散（MD）、各向异性分数（FA）等微观参数。与正常对照组相比，SVD组双侧MD值明显升高，双侧FA值降低，但差异无统计学意义。此外，NAA/Cho、Cho/Cr和NAA/Cr无显著性差异。本研究提示SVD认知功能损害的机制与白色结构的损害有关，而与脑代谢无关。
White matter lesion (WML) in magnetic resonance imaging is commonly observed in patients with cerebral small vessel disease (SVD), but the pathological mechanism of WML in SVD is still unclear. We observed the metabolism and microscopic anatomy of white matter in SVD patients. Twelve subjects clinically diagnosed with SVD and 6 normal control subjects were examined with magnetic resonance spectroscopy (MRS) and diffusion tensor imaging (DTI). The white matter at the centrum semiovale level was selected as the region of interest (ROI). The ROI metabolism parameters, including N-acetyl-l-aspartic acid (NAA), creatine (Cr), and choline (Cho) were measured by MRS. Microscopic parameters such as mean diffusion (MD) and fractional anisotropy (FA) in ROI were obtained by DTI. Compared with the normal control group, bilateral MD values in the SVD group were significantly elevated, whereas bilateral FA values in SVD were decreased, but the difference was not statistically significant. Additionally, NAA/Cho, Cho/Cr, and NAA/Cr showed no significant statistical differences. Our study suggests that the mechanisms of the SVD cognitive impairment are related to damage of the white matter structures rather than to brain metabolism.