Elevated serum interleukin-6 (IL-6) and IL-6 receptor concentrations in posttraumatic stress disorder following accidental man-made traumatic events
Elevated serum interleukin-6 (IL-6) and IL-6 receptor concentrations in posttraumatic stress disorder following accidental man-made traumatic events
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DOI：
10.1016/s0006-3223(98)00131-0
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发表时间：
1999-04-01
影响因子：
10.6
通讯作者：
Bosmans, E
中科院分区：
文献类型：
--
作者：
Maes, M;Lin, AH;Bosmans, E
背景：最近有报道称，创伤后应激障碍（PTSD）患者血清中白细胞介素-1 β (IL-1 β)，而非可溶性IL-2受体（sIL-2R）的浓度明显高于正常志愿者，并且人类的心理应激与促炎细胞因子如IL-6的分泌增加有关。方法：本研究的目的是通过测量血清IL-6、sIL-6R、sgp130 （IL-6信号转导蛋白）、sIL-1R拮抗剂（sIL-1RA；一种内源性IL-1受体拮抗剂）、CC16（内源性抗细胞因子）和sCD8 （T抑制细胞毒性抗原）来检测PTSD患者的炎症反应系统。结果：PTSD患者血清IL-6和sIL-6R浓度显著高于正常志愿者，但sgp130、sIL-RA、CC16和sCD8浓度不显著高于正常志愿者。PTSD合并重度抑郁患者血清sIL-6R浓度显著高于无重度抑郁的PTSD患者和正常志愿者。血清IL-6或sIL-6R与PTSD严重程度无显著相关性。结论：结果提示创伤后应激障碍与IL-6信号升高有关。据推测，应激诱导的促炎细胞因子的分泌参与了儿茶酚胺能调节焦虑反应。(C) 1999年生物精神病学学会。
Background: Recently, it has been reported that serum interleukin-1 beta (IL-1 beta), but not soluble IL-2 receptor (sIL-2R), concentrations were significantly higher in patients with posttraumatic stress disorder (PTSD) than in normal volunteers, and that psychological stress in humans is associated with increased secretion of proinflammatory cytokines, such as IL-6.Methods: The aim of the present study was to examine the inflammatory response system in patients with PTSD through measurements of serum IL-6, sIL-6R, sgp130 (the IL-6 signal transducing protein), sIL-1R antagonist (sIL-1RA; an endogenous IL-1 receptor antagonist), CC16 (an endogenous anticytokine), and sCD8 (the T suppressor-cytotoxic antigen).Results: Serum IL-6 and sIL-6R, but not sgp130, sIL-RA, CC16, or sCD8, concentrations were significantly higher in PTSD patients than in normal volunteers. Serum sIL-6R concentrations were significantly higher in PTSD patients with concurrent major depression than in PTSD patients without major depression and normal volunteers. There were no significant relationships between serum IL-6 or sIL-6R and severity measures of PTSD.Conclusions: The results suggest that PTSD is associated with increased IL-6 signaling. It is hypothesized that stress-induced secretion of proinflammatory cytokines is involved in the catecholaminergic modulation of anxiety reactions. (C) 1999 Society of Biological Psychiatry.