Age-associated alteration of serotonergic synaptic neurochemistry in rat rostral hypothalamus.
Age-associated alteration of serotonergic synaptic neurochemistry in rat rostral hypothalamus.
复制标题
大鼠下丘脑嘴端血清素能突触神经化学的年龄相关改变。
DOI：
10.1016/0197-4580(85)90052-1
复制
发表时间：
1985
影响因子：
4.2
通讯作者：
Slevin,JT
中科院分区：
文献类型：
--
作者：
Sparks,DL;Markesbery,WR;Slevin,JT
比较了年轻（3-4个月）和老年（25-26个月）Fischer 344-大鼠吻侧和尾侧下丘脑片段中单胺和代谢物的水平。幼兽的碎片之间没有差异。在衰老大鼠，5-羟基吲哚乙酸（5 HIAA）增加，在吻和尾侧下丘脑。5 HIAA/5 HT（5-羟色胺）的比率，5-羟色胺周转指数，增加只有嘴。嘴侧下丘脑中5 HIAA/5 HT的年龄相关性增加与[3 H]-螺哌隆结合减少相关。下丘脑MAO-A活性和血清酪氨酸、色氨酸水平无年龄相关性变化。
Levels of monoamines and metabolites in rostral and caudal hypothalamic fragments of young (3–4 months) and old (25–26 months) Fischer 344-rats were compared. There were no differences between fragments of young animals. In senescent rats, 5-hydroxyindoleacetic acid (5HIAA) increased in both rostral and caudal hypothalamus. The ratio 5HIAA/5HT (serotonin), an index of serotonin turnover, increased only rostrally. This age-related increase of 5HIAA/5HT in rostral hypothalamus was associated with a decrease in [3H]-spiperone binding. There were no age-related changes of MAO-A activity in the hypothalamus or of serum tyrosine or tryptophan levels.