Opposite effects of CD14/-260 on serum IgE levels in children raised in different environments
Opposite effects of CD14/-260 on serum IgE levels in children raised in different environments
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DOI：
10.1016/j.jaci.2005.05.003
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发表时间：
2005-09-01
影响因子：
14.2
通讯作者：
Martinez, FD
中科院分区：
文献类型：
--
作者：
Eder, W;Klimecki, W;Martinez, FD
背景资料：大多数复杂的疾病是基因组多态性和环境暴露之间相互作用的结果。目的：我们试图研究先前报道的CD 14启动子区多态性与疾病的关系。（CD 14/-260C -> T）和血清IgE水平与儿童暴露环境的关系。在624名生活在欧洲2个农村社区的儿童中，我们比较了CD 14/-260基因型与接触动物和与室内灰尘内毒素相关的总血清和特异性血清IgE水平。我们发现，CD 14/-260的C等位基因与经常与宠物接触的儿童中较高水平的总IgE和特异性血清IgE相关，而在与稳定动物经常接触的儿童中发现了相反方向的关联。动物暴露的这种改变效应不能用室内灰尘内毒素水平来解释。然而，在儿童与高水平的室内灰尘内毒素，C等位基因与特异性IgE较少，独立于动物exposation.Conclusion：由于CD 14是一种模式识别受体的微生物分子，结果表明，这种分子的类型和浓度存在于环境中强烈决定的方向之间的关联CD 14/-260和血清标志物的特应性。
Background: Most complex diseases are the result of interactions between polymorphisms in the genome and environmental exposures.Objective: We sought to investigate the previously reported association between a polymorphism in the promoter region of CD14 (CD14/-260C -> T) and serum IgE levels in relation to the environment to which children are exposed.Methods: In 624 children living in 2 rural communities in Europe, we compared total and specific serum IgE levels between the genotypes of CD14/-260 in relation to exposure to animals and in relation to house dust endotoxin.Results: We found that the C allele of CD14/-260 was associated with higher levels of both total and specific serum IgE to aeroallergens in children with regular contact with pets, whereas an association in the opposite direction was found in children with regular contact with stable animals. This modifying effect of animal exposure was not explained by levels of house dust endotoxin. However, in children with high levels of house dust endotoxin, the C allele was associated with less specific IgE, independently from animal exposure.Conclusion: Because CD14 is a pattern recognition receptor for microbial molecules, the results suggest that the type and concentrations of such molecules present in the environment strongly determine the direction of the association between CD14/-260 and serum markers of atopy.