The organization of projections from the amygdala to visual cortical areas TE and V1 in the macaque monkey
The organization of projections from the amygdala to visual cortical areas TE and V1 in the macaque monkey
复制标题
DOI：
10.1002/cne.20520
复制
发表时间：
2005-06-13
影响因子：
2.5
通讯作者：
Amaral, DG
中科院分区：
文献类型：
--
作者：
Freese, JL;Amaral, DG
通过向束状猕猴的杏仁核复合体注射顺行示踪剂，研究了杏仁核向视觉皮质区TE和V1的投射组织。杏仁核基底核的大细胞分裂和中间分裂在TE区域的背侧范围内产生了向浅层（I/II边界）和深层（V/VI）的大量突出。虽然大多数注射导致TE区浅层纤维和末端标记变重，但基底核最背侧注射在TE区深层产生了更密集的标记纤维和终端。V1区主要接收基底核大细胞分裂的突起，这些突起只在浅层终止。与TE区一样，杏仁核到V1区的投射分布在其背侧和横向。标记轴突在TE区浅层平均表现为11.67个变异/100 μ m，深层平均表现为8.74个变异/100 μ m。在V1区，我们观察到8.24个静脉曲张/100 μ m。使用共聚焦显微镜，我们确定在TE区和V1区，至少55%的示踪剂标记的静脉曲张与突触体素（突触囊泡的标记物）共定位，表明它们可能是突触扣。对这些变异样本的电子显微镜检查证实，标记钮扣在TE和V1区域形成突触。这些来自杏仁核的类似反馈的投影有可能调节视觉处理系统的关键区域。(c) 2005 Wiley-Liss, Inc。
We examined the organization of amygdaloid projections to visual cortical areas TE and V1 by injecting Anterograde tracers into the amygdaloid complex of Macaca fascicularis monkeys. The magnocellular and intermediate divisions of the basal nucleus of the amygdala gave rise to heavy projections to both superficial layers (border of I/II) and deep layers (V/VI) throughout the rostrocaudal extent of area TE. Although most of the injections led to heavier fiber and terminal labeling in the superficial layers of area TE, the most dorsal injections in the basal nucleus produced denser labeled fibers and terminals in the deep layers of area TE. Area V1 received projections primarily from the magnocellular division of the basal nucleus, and these terminated exclusively in the superficial layers. As in area TE, projections from the amygdala to area V1 were distributed throughout its rostrocaudal and transverse extents. Labeled axons demonstrated 11.67 varicosities/100 mu m on average in the superficial layers of area TE and 8.74 varicosities/100 mu m in the deep layers. ln area V1 we observed 8.24 varicosities/100 mu m. Using confocal inicroscopy, we determined that at least 55% of the tracer-labeled varicosities in areas TE and V1 colocalized synaptophysin, a marker of synaptic vesicles, indicating that they are probably synaptic boutons. Electron microscopic examination of a sample of these varicosities confirmed that labeled boutons formed synapses in areas TE and V1. These feedback-like projections from the amygdala have the potential of modulating key areas of the visual processing system. (c) 2005 Wiley-Liss, Inc.