Rodent Test of Attention and Impulsivity: The 5-Choice Serial Reaction Time Task.
Rodent Test of Attention and Impulsivity: The 5-Choice Serial Reaction Time Task.
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DOI：
10.1002/cpph.27
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发表时间：
2017-09-11
影响因子：
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通讯作者：
Silenieks, Leo B
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文献类型：
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作者：
Higgins, Guy A;Silenieks, Leo B
5-选择系列反应时任务（5-CSRTT）被广泛用于测量啮齿动物的注意力。该试验涉及经过训练的动物，以响应在五个位置之一呈现的短暂的、不可预测的视觉刺激。实验操作对反应速度和选择准确性的影响进行了测量，每个都与注意力表现有关。5-CSRTT也用于测量运动冲动。5-CSRTT改编自人类任务，可用于啮齿动物或灵长类动物，突出其翻译价值。这个程序的另一个优点是它对任务修改的适应性。一个例子是5选择连续性能任务，它有目标和非目标试验类型。总的来说，5-CSRTT已被证明是有价值的药物发现的努力，旨在确定新的代理人治疗中枢神经系统疾病和进一步了解的神经生物学过程的注意力和冲动。它的灵活性为实验者提供了相当大的范围，在这方面，任务继续发展。John Wiley & Sons，Inc.
The 5-choice serial reaction time task (5-CSRTT) is employed extensively to measure attention in rodents. The assay involves animals trained to respond to a brief, unpredictable visual stimulus presented in one of five locations. The effects of experimental manipulations on response speed and choice accuracy are measured, and each related to attentional performance. The 5-CSRTT is also used to measure motor impulsivity. Adapted from a human task, the 5-CSRTT can be employed with rodents or primates, highlighting its translational value. Another strength of this procedure is its adaptability to task modification. An example is the 5-choice continuous performance task, which has both target and non-target trial types. Overall, the 5-CSRTT has proven to be valuable for drug discovery efforts aimed at identifying new agents for the treatment of central nervous system disorders and for further understanding the neurobiological processes of attention and impulsivity. Its flexibility offers considerable scope to the experimenter, and in this respect the task continues to evolve. © 2017 by John Wiley & Sons, Inc.