Aristoyunnolin H attenuates extracellular matrix secretion in cardiac fibroblasts by inhibiting calcium influx
Aristoyunnolin H attenuates extracellular matrix secretion in cardiac fibroblasts by inhibiting calcium influx
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Aristoyunnolin H 通过抑制钙内流来减弱心脏成纤维细胞的细胞外基质分泌
DOI：
10.1007/s12272-016-0843-4
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发表时间：
2016-10
影响因子：
6.7
通讯作者：
Yin Sheng
中科院分区：
文献类型：
--
作者：
Chen Shao-rui;Zhang Wen-ping;Bao Jing-mei;Cheng Zhong-bin;Yin Sheng
Aristoyunnolin H is a novel aristophyllene sesquiterpenoid isolated from the traditional Chinese medicineAristolochia yunnanensis Franch. The present research was designed to explore the anti-fibrotic effects of aristoyunnolin H in adult rat cardiac fibroblasts (CFs) stimulated with angiotensin II (Ang II). Western blot analysis data showed that aristoyunnolin H reduced the upregulation of fibronectin (FN), connective tissue growth factor and collagen I(Col I) production induced by Ang II in CFs. By studying the dynamic intracellular changes of Ca2+, we further found that while aristoyunnolin H relieved the calcium influx, it has no effect on intracellular calcium store release. Meanwhile, aristoyunnolin H also inhibited the Ang II-stimulated phosphorylation of Ca2+/calmodulin-dependent protein kinase II. In conclusion, aristoyunnolin H may attenuate extracellular matrix secretion in vitro by inhibiting Ang II-induced calcium signaling.
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