The influence of NOS1AP gene polymorphisms and childhood abuse on antisocial personality disorder in Chinese male violent inmates
The influence of NOS1AP gene polymorphisms and childhood abuse on antisocial personality disorder in Chinese male violent inmates
复制标题
NOS1AP基因多态性和童年虐待对中国男性暴力囚犯反社会人格障碍的影响
DOI：
10.1002/pmh.1572
复制
发表时间：
2022
影响因子：
2.7
通讯作者：
Na Liu
中科院分区：
文献类型：
--
作者：
Jinyang Li;Lichen Ouyang;Xinyao Liu;Qiuyu Wang;Zhang Min;Gang Liu;Yuan Zhong;Ning Zhang;Chun Wang;Na Liu
反社会人格障碍（ASPD）是一种常见的行为模式，导致患者忽视或侵犯他人的权利。尽管其原因尚不清楚，但之前的研究表明，儿童虐待与反社会人格障碍密切相关。NOS 1AP基因与多种神经精神疾病相关，但尚未发现其与ASPD之间的联系。本研究招募了中国南京某监狱的ASPD和非ASPD男性受试者，他们曾犯下暴力犯罪。通过比较两组儿童的基因型、等位基因频率和儿童期虐待史，探讨NOS 1AP基因与儿童期虐待在ASPD发病中的交互作用。结果表明，NOS 1AP基因rs 945713多态性与ASPD相关，该SNP可能参与调节儿童期虐待对ASPD的影响。本研究发现，童年期创伤增加了暴力型成年男性服刑人员发生反社会人格障碍的风险;对于有反社会人格障碍的服刑人员，关注其童年期创伤，早期进行心理干预至关重要。
Antisocial personality disorder (ASPD) is a common behavioral pattern that causes sufferers to ignore or violate the rights of others. Though its cause is still unclear, previous studies have shown that childhood maltreatment is closely related to ASPD. The NOS1AP gene is associated with various neuropsychiatric diseases, but a linkage between it and ASPD has not yet been discovered. This study recruited ASPD and non‐ASPD male subjects who had committed violent crimes from a prison in Nanjing, China. By comparing the two groups' genotypes, allele frequencies, and histories of childhood abuse, we explored the interaction between the NOS1AP gene and childhood maltreatment on the pathogenesis of ASPD. The results showed that polymorphism rs945713 in the NOS1AP gene was associated with ASPD and furthermore that this SNP may be involved in regulating the effect of childhood abuse on ASPD. This study found that childhood trauma increases the risk of ASPD in violent adult male inmates; for prisoners with ASPD, it is critical to pay attention to their childhood trauma and take early psychological intervention.