Non-invasive measurement of oxygen saturation in the spinal vein using SWI: Quantitative evaluation under conditions of physiological and caffeine load
Non-invasive measurement of oxygen saturation in the spinal vein using SWI: Quantitative evaluation under conditions of physiological and caffeine load
复制标题
DOI：
10.1016/j.neuroimage.2010.08.020
复制
发表时间：
2011-01-01
期刊：
影响因子：
5.7
通讯作者：
Shirato, Hiroki
中科院分区：
文献类型：
--
作者：
Fujima, Noriyuki;Kudo, Kohsuke;Shirato, Hiroki
敏感性加权成像（SWI）已被用于定量和无创测量脑血氧饱和度。在这项研究中，我们使用SWI定量测量脊髓静脉的氧饱和度，以寻找生理或咖啡因引起的静脉氧合变化。5名健康志愿者在1)3种生理负荷（屏气，Bh；过度通气，Hv；吸入高浓度氧）下，使用1.5 t MR测量SWI。2)咖啡因负荷。计算脊髓前静脉血氧饱和度（ASV）。我们评估了生理负荷引起的血氧饱和度变化。我们还评估了摄入咖啡因后血氧饱和度的时间过程。在生理负荷测量中，5名受试者的平均氧饱和度Hv（0.75）显著低于对照组（0.80），而Bh（0.84）显著高于对照组（0.80）。Ox与对照组无显著差异（0.81）。摄入咖啡因后，血氧饱和度逐渐下降。血氧饱和度平均值分别为0.79 （0 min）、0.76 （20 min）、0.74 （40 min）和0.73 （60 min）。我们证明，与摄入咖啡因后0分钟相比，摄入咖啡因后40和60分钟的血氧饱和度有显著差异。总之，我们证明了使用SWI无创测量脊髓静脉氧饱和度的可行性。我们显示了生理负荷和咖啡因负荷下氧饱和度的变化，并建议这种方法是临床评估脊髓氧合的有用工具。(C) 2010爱思唯尔公司版权所有。
Susceptibility-weighted imaging (SWI) has been used for quantitative and non-invasive measurement of blood oxygen saturation in the brain. In this study, we used SWI for quantitative measurement of oxygen saturation in the spinal vein to look for physiological- or caffeine-induced changes in venous oxygenation. SWI measurements were obtained for 5 healthy volunteers using 1.5-T MR units, under 1) 3 kinds of physiological load (breath holding, Bh; hyperventilation, Hv; and inspiration of highly concentrated oxygen. Ox) and 2) caffeine load. Oxygen saturation in the anterior spinal vein (ASV) was calculated. We evaluated changes in oxygen saturation induced by physiological load. We also evaluated the time-course of oxygen saturation after caffeine intake. For the physiological load measurements, the average oxygen saturation for the 5 subjects was significantly lower in Hv (0.75) and significantly higher in Bh (0.84) when compared with control (0.80). There was no significant difference between Ox (0.81) and control. Oxygen saturation gradually decreased after caffeine intake. The average values of oxygen saturation were 0.79 (0 min), 0.76 (20 min), 0.74 (40 min), and 0.73 (60 min), respectively. We demonstrated a significant difference in oxygen saturation at 40 and 60 min after caffeine intake when compared with 0 min.In conclusion, we demonstrated the feasibility of using SWI for non-invasive measurement of oxygen saturation in the spinal vein. We showed changes in oxygen saturation under physiological as well as caffeine load and suggest that this method is a useful tool for the clinical evaluation of spinal cord oxygenation. (C) 2010 Elsevier Inc. All rights reserved.