Identification of a novel B-cell epitope of Hantaan virus glycoprotein recognized by neutralizing 3D8 monoclonal antibody.
Identification of a novel B-cell epitope of Hantaan virus glycoprotein recognized by neutralizing 3D8 monoclonal antibody.
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中和 3D8 单克隆抗体识别的汉坦病毒糖蛋白新 B 细胞表位的鉴定。
DOI：
10.1099/vir.0.045302-0
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发表时间：
2012-12
影响因子：
3.8
通讯作者：
Zhang F
中科院分区：
文献类型：
--
作者：
Jin B;Zhang Y;Ma Y;Yi J;Liu B;Xu Z;Zhang Y;Zhang C;Zhang F
Hantaan virus (HTNV), a member of the familyBunyaviridae, is a major agent causing haemorrhagic fever with renal syndrome, a high-mortality-rate disease threatening approximately 150 000 people around the world yearly. The 3D8 mAb displays a neutralizing activity to HTNV infection. In this study, the B-cell epitopes of HTNV glycoproteins (GPs) were finely mapped by peptide scanning. A new B-cell epitope882GFLCPEFPGSFRKKC896of HTNV, which locates on Gc, has been screened out from a set of 15-mer synthesized peptides covering the full-length of HTNV-GPs. It has been shown by the alanine-scanning technique that885C,893R,894K,895K and896C are the key amino acids of the binding sites of the GPs. The implications of identifying a novel B-cell epitope for hantavirus immunology and vaccinology are discussed.
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影响因子：
4.9
作者：
Rong Xu;Xiao Yan Yang;Dao-feng Yang;Chang Yong Zou;P. Gong;F. Zeng
通讯作者：
Rong Xu;Xiao Yan Yang;Dao-feng Yang;Chang Yong Zou;P. Gong;F. Zeng
影响因子：
1.7
作者：
Mir, Mohammed A.
通讯作者：
Mir, Mohammed A.
DOI：
10.1007/978-3-642-56753-7
发表时间：
2001
期刊：
--
影响因子：
--
作者：
F. Melchers;Basel M. Oldstone
通讯作者：
F. Melchers;Basel M. Oldstone
影响因子：
2.8
作者：
X. Lü;W. Yin;Qiao-xin Yang;Y. Lei;Jing Yang;M. Sun;M. Yao;Zhikai Xu;X. Xue
通讯作者：
X. Lü;W. Yin;Qiao-xin Yang;Y. Lei;Jing Yang;M. Sun;M. Yao;Zhikai Xu;X. Xue
影响因子：
5.4
作者：
Dowling, William;Thompson, Elizabeth;Schmaljohn, Connie
通讯作者：
Schmaljohn, Connie