Bacterial infection of endometrial stromal cells influences bovine herpesvirus 4 immediate early gene activation: a new insight into bacterial and viral interaction for uterine disease.
Bacterial infection of endometrial stromal cells influences bovine herpesvirus 4 immediate early gene activation: a new insight into bacterial and viral interaction for uterine disease.
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DOI：
10.1530/rep-08-0171
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发表时间：
2008-09
期刊：
影响因子：
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通讯作者：
Sheldon IM
中科院分区：
文献类型：
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作者：
Donofrio G;Ravanetti L;Cavirani S;Herath S;Capocefalo A;Sheldon IM
伽玛疱疹病毒牛疱疹病毒 4 (BoHV-4) 的实验性感染很少会引起疾病，但 BoHV-4 通常与牛的子宫疾病有关。子宫疾病涉及大肠杆菌等细菌的共同感染，这些细菌会刺激子宫内膜细胞产生前列腺素 E2 (PGE2)。 BoHV-4 复制依赖于立即早期 2 (IE2) 基因反式激活，在本研究中，PGE2、大肠杆菌或其脂多糖 (LPS) 上调子宫细胞中的 IE2 基因启动子。细菌合并感染对于 BoHV-4 子宫疾病很重要。
Experimental infection with the gammaherpesvirus Bovine herpesvirus 4 (BoHV-4) rarely establishes disease, yet BoHV-4 is commonly associated with uterine disease in cattle. Uterine disease involves co-infection with bacteria such as Escherichia coli, which stimulate the production of prostaglandin E2 (PGE2) by endometrial cells. BoHV-4 replication depends on Immediate Early 2 (IE2) gene transactivation, and in the present study, PGE2, E. coli or its lipopolysaccharide (LPS), up-regulated the IE2 gene promoter in uterine cells. Bacterial co-infection is important for BoHV-4 uterine disease.