A mathematical approach to bone tissue engineering
A mathematical approach to bone tissue engineering
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DOI：
10.1098/rsta.2009.0055
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发表时间：
2009-05-28
期刊：
影响因子：
5
通讯作者：
Doblare, M.
中科院分区：
文献类型：
--
作者：
Sanz-Herrera, J. A.;Garcia-Aznar, J. M.;Doblare, M.
组织工程作为组织修复和再生医学中最有前途的策略之一，正在生物医学领域得到巩固。在这一学科中，骨组织工程涉及使用负载细胞的多孔生物材料（即生物支架）来促进骨缺陷或骨质疏松症等疾病的骨组织再生，尽管它尚未纳入日常临床实践。特定骨组织工程应用的整体成功在很大程度上取决于支架设计参数，这消除了漫长且昂贵的临床方案。计算机模拟是一种有用的工具，可以减少动物实验，并有助于在简明的模型验证后确定最佳的针对特定患者的设计。在本文中，我们提出了一种基于多尺度框架的支架内骨再生的新颖数学方法。结果通过实际的支架微观结构呈现，展示了计算机模拟的潜力，以及它如何帮助在临床实践中实现骨组织工程的任务。
Tissue engineering is becoming consolidated in the biomedical field as one of the most promising strategies in tissue repair and regenerative medicine. Within this discipline, bone tissue engineering involves the use of cell-loaded porous biomaterials, i.e. bioscaffolds, to promote bone tissue regeneration in bone defects or diseases such as osteoporosis, although it has not yet been incorporated into daily clinical practice. The overall success of a particular bone tissue engineering application depends strongly on scaffold design parameters, which do away with long and expensive clinical protocols. Computer simulation is a useful tool that may reduce animal experiments and help to identify optimal patient-specific designs after concise model validation. In this paper, we present a novel mathematical approach to bone regeneration within scaffolds, based on a multiscale framework. Results are presented over an actual scaffold microstructure, showing the potential of computer simulation, and how it can aid in the task of making bone tissue engineering a reality in clinical practice.