Cutaneous large B-cell lymphoma of the leg masquerading as a chronic venous ulcer
Cutaneous large B-cell lymphoma of the leg masquerading as a chronic venous ulcer
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DOI：
10.1046/j.0007-0963.2001.04520.x
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发表时间：
2002-01-01
影响因子：
10.3
通讯作者：
Goerdt, S
中科院分区：
文献类型：
--
作者：
Garbea, A;Dippel, E;Goerdt, S
我们报告一位74岁的女性患者，原发性皮肤CD 20+，弥漫性大细胞B细胞淋巴瘤的小腿类似慢性不愈合的腿部溃疡。胸部、腹部和骨盆的计算机断层扫描（CT）没有证据表明全身受累;组织学和免疫组化显示右侧腹股沟轻微肿大的淋巴结显示皮肤病性淋巴结病。骨髓和外周血的参与被排除钻取活检和荧光激活细胞分选仪（FACS）分析的血液，分别。治疗性抗CD 20单克隆抗体利妥昔单抗375 mg m（-2）静脉注射，每周一次，持续7周，无不良反应，导致溃疡肿瘤中心轻微改善。不幸的是，反应没有维持，治疗7周后，患者开始在溃疡边缘出现新的肿瘤病变。开始局部放射治疗，并结合光子和电子束照射诱导B细胞淋巴瘤完全缓解。
We report on a 74-year-old female patient with a primary cutaneous CD20+, diffuse large cell B-cell lymphoma of the lower leg resembling a chronic non-healing leg ulcer. There was no evidence of systemic involvement on computed tomography (CT) scans of the chest, abdomen and pelvis; a slightly enlarged lymph node in the right groin showed dermatopathic lymphadenopathy on histology and immunohistochemistry. Involvement of the bone marrow and peripheral blood was ruled out by punch biopsy and fluorescent activated cell sorter (FACS) analysis of the blood, respectively. Therapeutic anti-CD20 monoclonal antibody rituximab was given at 375 mg m(-2) i.v. once weekly for 7 weeks, without adverse effects, resulting in a minor improvement in the centre of the ulcerated tumour. Unfortunately, the response was not maintained, and after 7 weeks of treatment the patient started to develop new tumour lesions at the border of the ulcer. Local radiotherapy was started and combined photon and electron beam irradiation induced complete remission of the B-cell lymphoma.