Obesity and polycystic ovary syndrome
Obesity and polycystic ovary syndrome
复制标题
DOI：
10.1111/j.1365-2265.2006.02587.x
复制
发表时间：
2006-08-01
影响因子：
3.2
通讯作者：
Franks, S.
中科院分区：
文献类型：
--
作者：
Barber, T. M.;McCarthy, M. I.;Franks, S.
多囊卵巢综合征(PCOS)的病因是复杂的、多因素的。然而，有许多证据表明，脂肪组织在PCOS病理的发展和维持中扮演着重要的角色。在患有多囊卵巢综合征的女性中，肥胖与症状严重程度密切相关，即使适度的体重减轻，通常也会显著改善月经规律、生育能力和高雄激素特征。这篇综述文章讨论了过度肥胖和PCOS之间可能存在的各种机制，包括胰岛素敏感性差异、类固醇激素代谢异常和脂肪细胞因子分泌的影响。更多地关注可用于减少过度肥胖对卵巢和代谢功能的影响的治疗方案对于多囊卵巢综合征的管理是至关重要的。
The aetiology of Polycystic Ovary Syndrome (PCOS) is complex and multifactorial. There is much evidence, however, to suggest that adipose tissue plays an important role in the development and maintenance of PCOS pathology. There is a close correlation between adiposity and symptom severity in women with PCOS, and even modest reductions in weight generally translate into significant improvements in menstrual regularity, fertility and hyperandrogenic features. This review article considers the various mechanisms that might underlie this link between excess adiposity and PCOS - including the effects of differential insulin sensitivity, abnormal steroid hormone metabolism and adipocytokine secretion. Greater attention to the therapeutic options available to reduce the impact of excess adiposity on ovarian and metabolic function is essential to the management of PCOS.