Immune responses to allogeneic and xenogeneic implants of collagen and collagen derivatives.
Immune responses to allogeneic and xenogeneic implants of collagen and collagen derivatives.
复制标题
对胶原蛋白和胶原蛋白衍生物的同种异体和异种植入物的免疫反应。
DOI：
10.1097/00003086-199011000-00043
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发表时间：
1990
影响因子：
4.2
通讯作者：
L. Ellingsworth
中科院分区：
文献类型：
--
作者：
Frank DeLustro;James R. Dasch;J. Keefe;L. Ellingsworth
尽管异种胶原蛋白为许多医疗应用提供了安全有效的生物材料，但很少有数据允许明确定义的器械的免疫学特征与其临床后遗症相关。一个主要的例外是使用可注射的牛真皮胶原蛋白进行软组织轮廓矫正。已在几种器械的临床有效性和安全性背景下研究了超敏反应的低发生率。研究结果表明，这种免疫通常导致治疗部位出现皮肤炎症的局部症状，随着植入物被宿主吸收而消退。相比之下，更具免疫原性的止血剂可能引发临床上不可见或与该应用不相关的更频繁或更强烈的免疫应答。用于骨修复和再生的胶原基器械的最新经验也表明，对其胶原或非胶原组分的免疫力的存在不一定预示不良临床后遗症。事实上，许多具体的数据表明，这种免疫可以作为一种附带现象存在，对骨生成没有影响。为了获得生物相容性的真实综合图像，必须采取重要步骤来正确表征生物材料，并确保免疫学、临床、组织学和其他相关实验室数据相互关联而不是孤立地查看。
Whereas xenogeneic collagen has provided a safe and effective biomaterial for numerous medical applications, there are few instances in which data permit the correlation of the immunologic profile of well-defined devices with their clinical sequelae. A major exception is the use of injectable bovine dermal collagen for soft-tissue contour correction. The low incidence of hypersensitivity has been studied in the context of clinical efficacy and safety with several devices. The findings indicate that such immunity usually results in the manifestation of local symptoms of dermal inflammation at sites of treatment that resolve as the implant is resorbed by the host. In contrast, more immunogenic hemostatic agents may elicit a more frequent or vigorous immune response that is not clinically visible or relevant in that application. Recent experiences with collagen-based devices for the repair and regeneration of bone have also demonstrated that the presence of immunity to their collagenous or non-collagenous components does not necessarily predict adverse clinical sequelae. Indeed, numerous specific data indicate that this immunity can exist as an epiphenomenon with no effect on osteogenesis. To get a true composite picture of biocompatibility, significant steps must be taken to characterize biomaterials properly and to ensure that immunologic, clinical, histologic, and other pertinent laboratory data are viewed in relation to one another and not in isolation.