Detecting subtle spontaneous language decline in early Alzheimer's disease with a picture description task
Detecting subtle spontaneous language decline in early Alzheimer's disease with a picture description task
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DOI：
10.1007/s10072-005-0467-9
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发表时间：
2005-10-01
影响因子：
3.3
通讯作者：
Venneri, A
中科院分区：
文献类型：
--
作者：
Forbes-McKay, KE;Venneri, A
目的是收集简单和复杂版本的图片描述任务的规范数据，该任务旨在评估阿尔茨海默病 (AD) 患者的自发言语和写作技能，并测试自发语言的某些方面是否可以区分正常和病理性认知衰退。招募了 240 名讲英语的健康志愿者参与这项规范性研究。还招募了 30 名临床诊断为轻度至中度可能 AD 的患者。年龄和教育程度影响自发口头和书面语言的某些方面，而性别对评估的任何变量没有影响。很大比例（> 70%）的 AD 患者在测量语义处理技能的量表上表现低于截止值。当使用复杂版本的任务时，即使在疾病的早期阶段也发现了缺陷。通过图片描述任务对自发语言技能进行前瞻性评估，即使在疾病的早期阶段，也有助于检测 AD 引起的细微自发语言障碍。
The objective was to collect normative data for a simple and a complex version of a picture description task devised to assess spontaneous speech and writing skills in patients with Alzheimer's disease (AD), and to test whether some aspects of spontaneous language can discriminate between normal and pathological cognitive decline. Two hundred and forty English-speaking healthy volunteers were recruited to participate in this normative study. Thirty patients with a clinical diagnosis of minimal to moderate probable AD were also recruited. Age and education influenced some aspects of spontaneous oral and written language whereas sex had no influence on any of the variables assessed. A high proportion (> 70%) of AD patients performed below cut-off on those scales that measured semantic processing skills. Deficits were detected even amongst those in the very early stage of the disease when the complex version of the task was used. Prospective assessment of spontaneous language skills with a picture description task is useful to detect those subtle spontaneous language impairments caused by AD even at an early stage of the disease.