Activation of Human Platelets Causes Post-translational Modifications to Cytoplasmic Dynein
Activation of Human Platelets Causes Post-translational Modifications to Cytoplasmic Dynein
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人血小板的激活导致细胞质动力蛋白的翻译后修饰
DOI：
10.1055/s-0038-1657651
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发表时间：
1997
影响因子：
6.7
通讯作者：
V. Calvert
中科院分区：
文献类型：
--
作者：
S. Rothwell;V. Calvert
Summary In our studies of human platelets we have detected the presence of the molecular motors kinesin and dynein. Dynein is present at a concentration (0.8 μg/g tissue) that is approximately 1/3 the concentration reported for neuronal tissue. Immunofluorescence microscopy of resting platelets shows that, while platelet microtubules are arranged in coiled hoops forming the marginal band in the cortical region of the platelet, dynein is distributed in a pattern of punctate staining throughout the cytoplasm of the platelets. Fractionation of unactivated platelets shows that dynein partitions to the soluble fraction. Stimulation of platelets with thrombin, ADP or epinephrine causes a partial translocation of dynein from the soluble fraction to the particulate fraction with thrombin being the most efficient agent at promoting this shift. Dynein intermediate chain recovered in the soluble fraction of disrupted platelets following activation displays a transient, time-dependent phosphorylation. In contrast, dynein intermediate chain recovered in the particulate fraction shows decreased phosphorylation. These results indicate that human platelets contain a complex microtubule-based system of motor proteins that is an integral part of the physiological changes occurring during platelet activation.
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血小板开放小管系统：最终的共同途径。
DOI：
--
发表时间：
1991
期刊：
Blood cells
影响因子：
--
作者：
Escolar,G;White,JG
通讯作者：
White,JG
人血小板细胞骨架中肌动蛋白丝的排列。
DOI：
--
发表时间：
1984
期刊：
The American journal of pathology
影响因子：
--
作者：
White,JG
通讯作者：
White,JG
DOI：
--
发表时间：
1983-08
期刊：
The American journal of pathology
影响因子：
--
作者：
J. White;G. Rao
通讯作者：
J. White;G. Rao
applaggin 对 GPIIb/IIIa 的 Arg-Gly-Asp 依赖性占据：血小板整合素内化和循环的证据。
影响因子：
20.3
作者：
Wencel-Drake,JD;Frelinger3rd,AL;Dieter,MG;Lam,SC
通讯作者：
Lam,SC
凝血酶受体：打开后关闭它们。
影响因子：
3.6
作者：
Brass,LF;Ahuja,M;Belmonte,E;Blanchard,N;Pizarro,S;Tarver,A;Hoxie,JA
通讯作者：
Hoxie,JA