Evaluation of WHO Criteria for Viral Failure in Patients on Antiretroviral Treatment in Resource-Limited Settings.
Evaluation of WHO Criteria for Viral Failure in Patients on Antiretroviral Treatment in Resource-Limited Settings.
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DOI：
10.1155/2011/736938
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发表时间：
2011
影响因子：
1.7
通讯作者：
Manabe YC
中科院分区：
文献类型：
--
作者：
Castelnuovo B;Sempa J;Agnes KN;Kamya MR;Manabe YC
我们的目标是评估持续病毒抑制的患者和有病毒血症发作的患者的结果。方法：研究方法。在乌干达开始接受抗逆转录病毒治疗并随访48个月的前瞻性队列中，患者根据病毒载量(VL)进行分类：(1)持续抑制：(VL≤1,000拷贝/毫升)(2)VL 1,001-10,000，或(3)VL>；10,000。结果。53例(11.2%)和84例(17.8%)患者分别首发中度和高度病毒血症。与病毒症患者相比，持续抑制的患者随着时间的推移，CD4+T细胞计数增加的情况更好(P<；.001)。当重复测量时，大多数病毒血症患者实现了病毒抑制。只有39.6%的中度病毒血症患者和19.1%的高度病毒血症患者最终需要转到二线(P=0.008)。结论。使用至少一次重复测量而不是一次VL测量可以避免60%到80%的不必要的切换。
Our objective was to evaluate outcomes in patients with sustained viral suppression compared to those with episodes of viremia. Methods. In a prospective cohort of patients started on ART in Uganda and followed for 48 months, patients were categorized according to viral load (VL): (1) sustained-suppression: (VL ≤1,000 copies/mL) (2) VL 1,001–10,000, or (3) VL >10,000. Results. Fifty-Three (11.2%) and 84 (17.8%) patients had a first episode of intermediate and high viremia, respectively. Patients with sustained suppression had better CD4+ T cell count increases over time compared to viremic patients (P < .001). The majority of patients with viremia achieved viral suppression when the measurement was repeated. Only 39.6% of patients with intermediate and 19.1% with high viremia eventually needed to be switched to second line (P = .008). Conclusions. The use of at least one repeat measurement rather than a single VL measurement could avert from 60% to 80% of unnecessary switches.