Mouse Modeling in oncologic preclinical and translational research
Mouse Modeling in oncologic preclinical and translational research
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DOI：
10.1158/1078-0432.ccr-06-0482
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发表时间：
2006-09-15
影响因子：
11.5
通讯作者：
Pandolfi, Pier P.
中科院分区：
文献类型：
--
作者：
Carver, Brett S.;Pandolfi, Pier P.
随着科技的进步，我们操纵小鼠基因组的能力使我们能够评估特定基因改变对体内肿瘤发生的影响。这已经允许并将允许我们定义描述肿瘤起始、侵袭和转移性疾病进展过程的分子途径。此外，这些模型可以作为鉴定新的治疗分子靶点以及评估靶向治疗效果的良好平台。最终，这将从临床前小鼠模型试验转化为癌症患者临床试验和方案的发展。本文综述了小鼠模型在肿瘤转化研究中的应用。
Through scientific and technological advancements, our ability to manipulate the mouse genome has allowed us to evaluate the effect of specific genetic alterations on in vivo tumorigenesis. This has allowed and will allow us to define molecular pathways describing the processes of tumor initiation, invasion, and progression to metastatic disease. Additionally, these models may serve as an excellent platform for the identification of novel molecular targets for therapy as well as to evaluate the efficacy of targeted therapies. Ultimately this will translate from preclinical mouse model trials to the development of clinical trials and protocols for cancer patients. Here we review the usefulness of mouse modeling in oncologic translational research.