Excess Zinc Ions Induce the Inhibition of Carboxypeptidase A Activity by the Conformational Change
Excess Zinc Ions Induce the Inhibition of Carboxypeptidase A Activity by the Conformational Change
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过量锌离子通过构象变化抑制羧肽酶 A 活性
DOI：
10.1080/00958978808080701
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Y. Kidani
中科院分区：
文献类型：
--
作者：
J. Hirose;Y. Kidani
本文用动力学和平衡透析法研究了过量锌离子在pH8.2时对酶活性的抑制机理。过量的锌离子是肽和酯底物的竞争性抑制剂。这种行为被认为是由于过量的锌离子将酶固定在底物不能结合的构象中而引起的。
Abstract The mechanism for inhibition of enzyme activity by excess zinc ions has been studied by kinetic and equilibrium dialysis method at pH 8.2. Excess zinc ions were competitive inhibitor for both peptide and ester substrates. This behavior is believed to arise by the excess zinc ions fixing the enzyme in a conformation to which substrate cannot bind.