Current and future perspectives of multifunctional magnetic nanoparticles based controlled drug delivery systems
Current and future perspectives of multifunctional magnetic nanoparticles based controlled drug delivery systems
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DOI：
10.1016/j.jddst.2021.102946
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发表时间：
2022-01-11
影响因子：
5
通讯作者：
Assiri, Mohammed Ali
中科院分区：
文献类型：
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作者：
Aslam, Hira;Shukrullah, Shazia;Assiri, Mohammed Ali
基于磁性纳米粒子的药物递送系统（MDDS）由于其卓越的生物相容性和多功能的装载能力而比其他已知系统更受欢迎。 MDDS一般由氧化铁（Fe3O4、Fe2O3等）超顺磁性纳米粒子组成。有机或无机改变可用于对其表面进行功能化，以有效控制药物并将其输送到目标位置。 MDDSs的作用机制比其他药物递送系统更先进，因为它具有较强的靶向能力和较小的副作用。 MDDS 可以通过靶向配体组装、磁性纳米粒子组装和药物负载来创建。据报道，磁性纳米粒子（MNP）和相关组合物由于其对外部磁场的敏感响应而成为创新的递送方法之一。本文重点关注为符合独特医疗应用标准的药物输送而设计的理想系统的磁性和物理化学特性。本文还讨论了为未来临床应用构建复杂 MDDS 时出现的表面改变和功能化问题。最后，本讨论包括用聚合物、脂质体、二氧化硅等对磁性纳米颗粒进行表面涂层，以将其用作癌症检测和治疗中的MDDS。这项研究还强调了 MDDS 交付系统的挑战和最新发展。
Magnetic nanoparticle-based drug delivery systems (MDDSs) are gaining popularity over other known systems due to their superior biocompatibility and versatile loading capabilities. MDDSs are generally made up of iron oxide (Fe3O4, Fe2O3, etc.) superparamagnetic nanoparticles. Organic or inorganic alterations can be used to functionalize their surface for effective control over and drug delivery to the targeted place. The mechanism of MDDSs is more advanced than other drug delivery systems due to their strong targeting power and lesser side effects. MDDSs can be created by targeted ligand assembling, magnetic nanoparticle assemblage and loading of drugs. Magnetic nanoparticles (MNPs) and associated assemblages are reported as one of the innovative delivery methods due to their sensitive responsiveness to external magnetic fields. This paper is focused on magnetic and physicochemical properties of the ideal systems designed for drug delivery that fit in the criteria of unique medical applications. The surface alterations and functionalization concerns that come up when building complicated MDDSs for future clinical application are also discussed in this article. Finally, this discussion includes surface coating of magnetic nanoparticles with polymers, liposomes, silica etc. for their use as MDDSs in cancer detection and therapy. This study also highlights the challenges and latest developments in MDDSs delivery systems.