Magnolol exhibits anti-inflammatory and neuroprotective effects in a rat model of intracerebral haemorrhage
Magnolol exhibits anti-inflammatory and neuroprotective effects in a rat model of intracerebral haemorrhage
复制标题
厚朴酚在脑出血大鼠模型中表现出抗炎和神经保护作用
DOI：
10.1016/j.bbi.2018.12.018
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发表时间：
2019-03
期刊：
影响因子：
--
通讯作者：
胡治平
中科院分区：
文献类型：
--
作者：
周芳芳;蒋正;阳彬彬;胡治平
脑出血(ICH)可引起炎症反应，可导致严重的继发性损伤。近年来的研究表明，厚朴酚(Magolol，MG)通过抑制炎症反应对缺血性卒中具有保护作用。然而，MG对脑出血(ICH)的抗炎作用尚不清楚。在此，我们报道了MG对大鼠脑出血模型的保护作用是通过抗炎过程实现的。结果发现，MG能显著降低脑出血大鼠的脑含水量，恢复血脑屏障，通过减少神经胶质细胞的活化，减少中性粒细胞的浸润，减少炎症因子(IL-1β、肿瘤坏死因子-α和基质金属蛋白酶-9)的产生，从而减轻神经功能障碍。这些结果表明，MG减轻了脑出血模型的炎性损伤，改善了神经预后。
Intracerebral haemorrhage (ICH) induces inflammation, which can cause severe secondary injury. Recent evidence has suggested that magnolol (MG) has a protective effect against ischaemic stroke through the inhibition of inflammation. However, the anti-inflammatory effect of MG in intracerebral haemorrhage (ICH) remains unclear. Here, we report that the protective effect of MG in a rat model of ICH can be achieved by anti-inflammatory processes. We found that MG administration significantly reduced the brain water content, restored the blood-brain barrier (BBB) and subsequently attenuated neurological deficits via decreasing the activation of glial cells, decreasing the infiltration of neutrophils and reducing the production of pro-inflammation factors (IL-1β, TNF-α and MMP-9) in a rat model of ICH. These results suggest that MG reduced inflammatory injury and improved neurological outcomes in ICH model.
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