Non-fatal overdose among a cohort of active injection drug users recruited from a supervised injection facility
Non-fatal overdose among a cohort of active injection drug users recruited from a supervised injection facility
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DOI：
10.1080/00952990802122457
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发表时间：
2008-01-01
影响因子：
2.7
通讯作者：
Wood, Evan
中科院分区：
文献类型：
--
作者：
Milloy, M. -J. S.;Kerr, Thomas;Wood, Evan
注射吸毒者中的非致命性过量是造成严重发病的一个原因。由于有人建议，监督注射设施（SIF）可能会增加过量的风险，我们试图评估一组SIF用户中的非致命性过量的模式。我们检查了最近的非致命性过量经验的参与者参加了一项前瞻性研究IDU招募从北美第一个医疗监督的安全注射设施。使用广义估计方程（GEE）确定近期非致死性过量的相关性。在研究期间招募了1，090人，其中317人（29.08%）为女性。基线时，638例（58.53%）报告了非致死性药物过量史，97例（8.90%）报告了过去6个月内至少1例非致死性药物过量。该比例在整个研究期间保持大致恒定。在多变量GEE分析中，与近期非致命性药物过量相关的因素包括：性交易参与（调整后的比值比[AOR]：1.45 [95%置信区间[CI] 1.07-1.99]，p = 0.02）和公共场所药物使用（AOR：1.50 [95% CI 1.09-2.06]; p = 0.01）。在单变量（比值比：1.05，p = 0.73）或多变量分析（AOR：1.01，p = 0.96）中，≥ 75%注射使用SIF与近期非致死性药物过量无关。报告近期非致死性用药过量的个体比例在研究期间没有变化。我们的研究结果表明，注射吸毒者的亚群可能受益于过量预防干预措施。我们的研究结果反驳了SIF可能增加过量可能性的建议。
Non-fatal overdose among injection drug users (IDU) is a source of significant morbidity. Since it has been suggested that supervised injecting facilities (SIF) may increase risk for overdose, we sought to evaluate patterns of non-fatal overdose among a cohort of SIF users. We examined recent non-fatal overdose experiences among participants enrolled in a prospective study of IDU recruited from within North America's first medically supervised safer injecting facility. Correlates of recent non-fatal overdoses were identified using generalized estimating equations (GEE). There were 1,090 individuals recruited during the study period of which 317 (29.08%) were female. At baseline, 638 (58.53%) reported a history of non-fatal overdose and 97 (8.90%) reported at least one non-fatal overdose in the last six months. This proportion remained approximately constant throughout the study period. In the multivariate GEE analysis, factors associated with recent non-fatal overdose included: sex-trade involvement (Adjusted Odds Ratio [AOR]: 1.45 [95% Confidence Interval [CI] 1.07-1.99], p = 0.02) and public drug use (AOR: 1.50 [95% CI 1.09-2.06]; p = 0.01). Using the SIF for = 75% of injections was not associated with recent non-fatal overdose in univariate (Odds Ratio: 1.05, p = 0.73) or multivariate analyses (AOR: 1.01, p = 0.96). The proportion of individuals reporting recent non-fatal overdose did not change over the study period. Our findings indicate that a sub-population of IDU might benefit from overdose prevention interventions. Our findings refute the suggestion that the SIF may increase the likelihood of overdose.