Cross sectional observation of the effects of carbon disulphide on the nervous system, endocrine system, and subjective symptoms in rayon manufacturing workers.
Cross sectional observation of the effects of carbon disulphide on the nervous system, endocrine system, and subjective symptoms in rayon manufacturing workers.
复制标题
二硫化碳对人造丝生产工人神经系统、内分泌系统和主观症状影响的横断面观察。
DOI：
10.1136/oem.55.7.473
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发表时间：
1998
影响因子：
4.9
通讯作者：
H. Sakurai
中科院分区：
文献类型：
--
作者：
T. Takebayashi;K. Omae;C. Ishizuka;T. Nomiyama;H. Sakurai
目的：启动了一项前瞻性队列研究，以澄清目前暴露于二硫化碳（CS2）的水平是否足够低，以防止发生亚临床健康损害或改善由于过去的高暴露对健康的影响。本文介绍了接触CS_2对神经和内分泌系统的影响，以及基线观察中的主观症状。方法：在日本11家人造丝工厂的432名暴露于CS2的男工和402名参考工人中，评价了CS2对正中神经传导速度、神经行为和心理测试以及与溶剂相关的主观症状的影响。调整了潜在的混杂因素，如年龄或饮酒。暴露于CS2被二分或分为三组的工作类型。研究结果：在纺纱和精炼过程中接触CS2的工人中，观察到运动神经传导速度（-1.9 m/s）和感觉神经传导速度（顺向神经传导速度为-0.91 m/s，逆向神经传导速度为-1.1 m/s）降低。小，但显着增加被发现在自评抑郁量表得分和减少数字跨度（向后）暴露于CS2的工人。在54项主观症状中，许多症状加重，即头重、头晕、突然站起后昏厥、震颤、迟钝、四肢皮肤敏感性增加、抓握力降低、性欲降低和皮肤粗糙增加。内分泌指标-糖化血红蛋白浓度-也在接触CS2的工人中增加。结论：CS2对工人的神经系统和糖代谢有亚临床效应。一种解释是，相对较高的暴露于CS2在过去可能会导致这些，但影响仍然没有完全改善下，目前暴露于CS2。另一种可能性是，目前暴露于CS2可能导致这些阳性结果。有必要进行后续观察，以澄清这些问题。
OBJECTIVES: A prospective cohort study was initiated to clarify whether the current level of exposure to carbon disulphide (CS2) is low enough to prevent occurrence of subclinical health impairments or to ameliorate health effects due to past high exposure. This paper describes the effects of exposure to CS2 on the nervous and endocrine systems, and the subjective symptoms in a baseline observation. METHODS: The effects were evaluated of CS2 on the median nerve conduction velocity, neurobehavioural and psychological tests, and subjective symptoms related to solvents in 432 male workers exposed to CS2 and 402 reference workers from 11 rayon factories in Japan. Adjustment was made for potential confounding factors such as age or alcohol drinking. Exposure to CS2 was either dichotomised or categorised into three groups by job type. RESULTS: Reductions were observed in motor (-1.9 m/s) and sensory (-0.91 m/s for orthodromic and -1.1 m/s for antidromic) nerve conduction velocities in the workers exposed to CS2 at the spinning and refining processes. Small but significant increases were found in self rated depression scale score and decrease in digit span (backward) in the workers exposed to CS2. Of 54 subjective symptoms many were increased--namely, heavy feeling in the head, light headedness, fainting after suddenly standing up, tremor, dullness, and increased sensitivity of skin in the extremities, reduced grasping power, reduced sexual desire, and increased rough skin. The endocrinological indicator--the concentration of glycosylated haemoglobin--was also increased in the workers exposed to CS2. CONCLUSIONS: Subclinical effects on the nervous system and on glucose metabolism were found in the workers exposed to CS2. One interpretation is that relatively higher exposure to CS2 in the past may induce these, but the effects are still not entirely ameliorated under the current exposure to CS2. Another possibility is that the current exposure to CS2 may cause these positive findings. A follow up observation is necessary to clarify these questions.