AN ORGAN-SPECIFIC DIFFERENTIATION GENE, PHA-1, FROM CAENORHABDITIS-ELEGANS
AN ORGAN-SPECIFIC DIFFERENTIATION GENE, PHA-1, FROM CAENORHABDITIS-ELEGANS
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DOI：
10.1126/science.250.4981.686
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发表时间：
1990-11-02
期刊：
影响因子：
56.9
通讯作者：
SCHNABEL, R
中科院分区：
文献类型：
--
作者：
SCHNABEL, H;SCHNABEL, R
Embryonic lethal mutations in the nematode Caenorhabditis elegans were generated and screened for phenotypes that suggest regulatory functions in order to identify genes involved in the control of early development. In embryos homozygous for mutations in one such gene, pha-1, the pharynx fails to undergo late differentiation and morphogenesis. Early pharynx development is not affected; thus, pha-1 controls the latter stages of this developmental process. All markers specific for differentiation in various pharyngeal cell types tested are affected, suggesting that pha-1 acts in an organ-specific, rather than cell type-specific, manner. The temperature-sensitive phases of both temperature-sensitive mutations indicate that pha-1 function is required solely during midembryogenesis, shortly before the onset of morphogenesis.
