Sleep Disruption, Safety Learning, and Fear Extinction in Humans: Implications for Posttraumatic Stress Disorder.
Sleep Disruption, Safety Learning, and Fear Extinction in Humans: Implications for Posttraumatic Stress Disorder.
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DOI：
10.1007/7854_2017_31
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发表时间：
2018
影响因子：
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通讯作者：
L. D. Straus;S. Drummond;V. Risbrough;S. Norman
中科院分区：
文献类型：
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作者：
L. D. Straus;S. Drummond;V. Risbrough;S. Norman
恐惧学习对于创伤后应激障碍（PTSD）症状的发展和维持至关重要，而安全学习和消退对于康复是必要的。动物模型的研究表明，睡眠中断，特别是REM睡眠片段，会干扰安全学习和灭绝过程，最近，研究将这些发现扩展到人类。这里介绍了对人类文献的讨论，其中主要包括健康人类对照受试者的实验研究。提出了恐惧学习、睡眠中断、安全学习和消退受损之间关系的理论模型，为睡眠中断及其与PTSD的关系提供了一个解释框架。总的来说，研究结果表明，睡眠中断在PTSD症状的发展和维持中起着重要作用，因此在PTSD治疗中提出了一个重要的可修改目标。
Fear learning is critical in the development and maintenance of posttraumatic stress disorder (PTSD) symptoms, and safety learning and extinction are necessary for recovery. Studies in animal models suggest that sleep disruption, and REM sleep fragmentation in particular, interfere with safety learning and extinction processes, and recently, studies are extending these findings to humans. A discussion of the human literature is presented here, which largely consists of experimental studies in healthy human control subjects. A theoretical model for the relationship between fear learning, sleep disruption, and impaired safety learning and extinction is proposed, which provides an explanatory framework for sleep disruption and its relationship to PTSD. Overall, findings suggest that sleep disruption plays a role in the development and maintenance of PTSD symptoms, and thus presents an important modifiable target in PTSD treatment.