POSTREPLICATION REPAIR OF DNA IN MAMMALIAN-CELLS
POSTREPLICATION REPAIR OF DNA IN MAMMALIAN-CELLS
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DOI：
10.1016/0024-3205(74)90018-6
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发表时间：
1974-01-01
期刊：
影响因子：
6.1
通讯作者：
LEHMANN, AR
中科院分区：
文献类型：
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作者：
LEHMANN, AR
Ys®外来电话拥有vecheniema为rmoving或规避各种病变是他们的DNA，这一直是eubect的审查在这个领域由8 trause（1）.许多损伤保留在受损细胞的DNA中，而不阻止复制的发生。DNA的复制修复可以定义为最广泛的意义，即DNA复制机制处理亲本DNA链损伤的方式。如果受损的碱基被错误地复制，这可能导致细胞死亡，突变和可能致癌。因此，这一过程非常重要。本文主要讨论紫外线（W）照射引起的davege的消失。严格地说，这不是一个修复过程，因为休息室是这样的，即没有删除。它与DNA复制密切相关。细菌可以通过光复活去除W-诱导的环丁烷嘧啶脱氧核糖核酸（a），光诱导的嘧啶脱氧核糖核酸原位分裂，在体内未被检测到，是胎盘细胞（参考文献1）。(2))，ar（B），其中oleo存在于人细胞中（3），但在啮齿动物细胞中仅以非常有限的程度存在。尽管这种婚姻mamvslian细胞的能力差，以消除嘧啶潜水员，他们可以在一般情况下生存W flumcee产生105-108这样的病变每个细胞。
Ys® alien calls possess vecheniema for rmoving or circumventing various lesions is their DNA, and this has been the eub~ ect of a review in this aeries by 8trause (1). Many lesions remain in the DNA in damaged cells, without pre venting replication irov taking place. Poetreplication repair of DNA may be defined is its broadest sense ae the manner is which the DNA replication machinery copes with lesions in the parental DNA strands. Ii damaged bases are copied incorrectly, this may lead to cell death, mutation and possibly carcinogeneeie. The process ie therefore of great importance. It will be diecussed principally with regard to davege ceased by ultraviolet (W) irradiation. Strictly speaking it ie not a repair process, since the lounge ae such ie not removed. It ie closely associated with DNA replication. Bacteria can remove W-induced cyclobutane pyrimidine divers cram DNA (a) by photoreactivation, a light-induced splitting of pyrimidine diniere in situ, which has not been detected in vivo is placental eiammale (reviewed in Ref.(2)), ar (b) by excision repair, which oleo occurs in human cells (3) but only to a very limited extent in rodent cells. Despite this poor ability of marry mamvslian cells to remove pyrimidine divers, they can in general survive W flumcee which produce 105-108 such lesions per cell.