Microbubble Radiation Force-Induced Translation in Plane-Wave Versus Focused Transmission Modes.
Microbubble Radiation Force-Induced Translation in Plane-Wave Versus Focused Transmission Modes.
复制标题
平面波与聚焦传输模式中微泡辐射力诱导的平移。
DOI：
10.1109/tuffc.2019.2937158
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Tortoli,Piero
中科院分区：
文献类型：
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作者：
Guidi,Francesco;Supponen,Outi;Upadhyay,Awaneesh;Vos,HendrikJ;Borden,MarkAndrew;Tortoli,Piero
由于一次辐射力的作用，以前在单元件和阵列超声探头的焦区观察到了微气泡的位移。这一效应已被利用来增加微泡与靶向内皮之间的接触，用于药物输送和超声分子成像。在这项研究中，深入研究了与平面波(PW)传输相关的微气泡位移，并与聚焦波(FW)传输在脉冲重复频率、脉冲长度(BLS)、峰值负压和传输频率范围内获得的微气泡位移进行了比较。在PW模式中，根据实验条件，在某些情况下，位移始终较高(例如，当在PRF=4 kHz时使用最长的BL时，增加28%)，并且与FW模式相比，轴向位移在空间上更加均匀。对测量的位移的统计分析表明，与瞬时峰值微泡位移相比，统计量的频率依赖性略有不同，这可能表明需要考虑测试微泡总数内的尺寸范围。
Due to the primary radiation force, microbubble displacement has been observed previously in the focal region of single-element and array ultrasound probes. This effect has been harnessed to increase the contact between the microbubbles and targeted endothelium for drug delivery and ultrasound molecular imaging. In this study, microbubble displacements associated with plane-wave (PW) transmission are thoroughly investigated and compared to those obtained in focused-wave (FW) transmission over a range of pulse repetition frequencies, burst lengths (BLs), peak negative pressures, and transmission frequencies. In PW mode, the displacements, depending upon the experimental conditions, are in some cases consistently higher (e.g., by 28%, when the longest BL was used at PRF = 4 kHz), and the axial displacements are spatially more uniform compared to FW mode. Statistical analysis on the measured displacements reveals a slightly different frequency dependence of statistical quantities compared to transient peak microbubble displacements, which may suggest the need to consider the size range within the tested microbubble population.