Movement of wax particles by contractions in the isolated opossum esophagus.
Movement of wax particles by contractions in the isolated opossum esophagus.
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通过离体负鼠食道的收缩来移动蜡颗粒。
DOI：
10.1152/ajpgi.1990.258.1.g164
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Schulze-Delrieu,K
中科院分区：
文献类型：
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作者：
Ren,J;Schulze-Delrieu,K
我们研究了离体平滑肌负鼠食管的收缩是否可以推动管腔内容物。将蜡颗粒置于体外食管中，通过主要刺激食管固有神经（使用0.5 ms的电脉冲）或直接刺激食管肌肉（使用0.5 s的脉冲）诱发食管收缩。直接肌肉刺激和神经刺激产生类似幅度的环形肌肉收缩，但只有神经刺激与传播环收缩和纵向肌肉收缩。蜡颗粒的运动发生后，所有的刺激反应的21%。蜡粒的逆向运动是逆向运动的10倍。与神经刺激相比，蜡运动发生的频率较低，距离较短。当食管纵向缩短时，蜡状物移动的距离增加。运动发生在收缩反应的后期，速度小于环收缩。此外，环收缩通过了粒子。环肌收缩幅度对推进的发生没有预测价值。离体食管可以将管腔内容物向外流方向推进，这一发现支持了这一论点，即扩张主要是平滑肌食管的内在神经肌肉组织的功能。
We investigated whether the contractions of the isolated smooth muscle opossum esophagus can propel luminal contents. Wax particles were placed into the esophagus in vitro, and esophageal contractions were evoked by stimulating either primarily the intrinsic esophageal nerves (using electrical pulses of 0.5 ms) or the esophageal muscle directly (using pulses of 0.5 s). Direct muscle stimulation and neural stimulation produced circular muscle contractions of similar amplitude, but only neural stimulation was associated with a propagating ring contraction and longitudinal muscle contraction. Movement of the wax particle occurred after 21% of all stimulus responses. Aborad movement of the wax particle was 10 times as common as was its orad movement. Wax movement occurred less commonly and over shorter distance with muscle as compared with neural stimulation. The distance the wax moved was enhanced when the esophagus was allowed to shorten in its longitudinal axis. Movement occurred late during the contraction response and at velocities less than that of the ring contraction. Also, the ring contraction passed over the particle. The amplitude of circular muscle contractions had no predictive value for the occurrence of propulsion. The finding that the isolated esophagus can propel luminal contents in the aborad direction supports the thesis that peristalsis is primarily a function of the intrinsic neuromuscular organization of the smooth muscle esophagus.