The Effect of a High-Fat Diet on the Development of Abdominal Aortic Aneurysm in a Vascular Hypoperfusion-induced Animal Model
The Effect of a High-Fat Diet on the Development of Abdominal Aortic Aneurysm in a Vascular Hypoperfusion-induced Animal Model
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DOI：
10.1159/000481780
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发表时间：
2018-01-01
影响因子：
1.7
通讯作者：
Moriyama, Tatsuya
中科院分区：
文献类型：
--
作者：
Hashimoto, Keisuke;Kugo, Hirona;Moriyama, Tatsuya
腹主动脉瘤（AAA）是一种以肾下主动脉慢性炎症为特征的血管疾病。大多数AAA病例在破裂前无症状，AAA破裂患者的死亡率非常高。目前，饮食习惯和AAA发展之间的关系仍不清楚。在这项研究中，我们在血管低灌注诱导的动物模型中评估了高脂饮食对AAA发展的影响。与对照组相比，高脂组的AAA破裂风险和AAA直径显著增加。与对照组相比，高脂组血管壁中脂肪细胞的数量和大小显著增加。此外，与无脂肪细胞的区域相比，有脂肪细胞的区域中的胶原阳性切片显著减少。有脂肪细胞的部位基质金属蛋白酶（MMP）-2、MMP-9、MMP-1 - 2的蛋白水平和巨噬细胞阳性面积也显著高于无脂肪细胞的部位。这些数据表明，AAA破裂的风险增加，通过加速慢性炎症，由于在高脂肪组的血管壁脂肪细胞的积累。(C)2018 S. Karger AG，巴塞尔
Abdominal aortic aneurysm (AAA) is a vascular disease characterized by chronic inflammation in the infra renal aorta. Most cases of AAA remain asymptomatic until rupture, and the mortality rate of patients with AAA rupture is very high. Currently, the relation between dietary habits and AAA development remains unknown. In this study, we evaluated the effects of a high-fat diet on the development of AAA in a vascular hypoperfusion-induced animal model. The risk of AAA rupture and AAA diameter in the high-fat group significantly increased compared with those in the control group. The number and size of adipocytes in the vascular wall in the high-fat group significantly increased as compared with those in the control group. Additionally, the collagen-positive sections in the areas with adipocytes significantly decreased as compared with those without adipocytes. The protein levels of matrix metalloproteinase (MMP)-2, MMP-9, and MMP-1 2, and macrophage-positive areas in the parts with adipocytes also significantly increased as compared with those without adipocytes. These data suggested that AAA rupture risk increased through accelerating chronic inflammation due to the accumulation of adipocytes in the vascular wall in the high-fat group. (C) 2018 S. Karger AG, Basel