ISLET CELL TRANSPLANTATION IN DIABETIC DOGS - STUDIES OF GRAFT FUNCTION AND STORAGE
ISLET CELL TRANSPLANTATION IN DIABETIC DOGS - STUDIES OF GRAFT FUNCTION AND STORAGE
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DOI：
10.1002/bjs.1800711007
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发表时间：
1984-01-01
影响因子：
9.6
通讯作者：
FARNDON, JR
中科院分区：
文献类型：
--
作者：
ALDERSON, D;WALSH, TN;FARNDON, JR
胰岛细胞移植是胰岛素依赖型糖尿病（IDD）的潜在治疗方法，假设生理激素释放导致生化正常，这反过来又降低了长期糖尿病并发症的发生率。这些实验试图在大型动物中建立IDD的代谢模型，并研究胰岛素治疗和胰岛移植的效果。在证明移植成功后，进一步的研究检查了从单个供体创建多个移植物及其长期保存的可行性。用次优胰岛素治疗的完全胰腺切除犬在生化上与人IDD相同，当给予更合适剂量的胰岛素时，代谢改善而不恢复正常。胰岛细胞自体移植使这些动物代谢正常，除了持续的葡萄糖耐量受损。分离技术允许生产至少两个受体移植物，并在移植物冷冻保存后取得了一定的成功。这些实验证实了胰岛移植的理论背景，并证明了其在同种异体移植前的大型动物模型中的适用性。
Islet cell transplantation is a potential treatment for insulin-dependent diabetes (IDD), assuming that physiological hormone release results in biochemical normality which, in turn, reduces the incidence of long-term diabetic complications. These experiments sought to create a metabolic model of IDD in a large animal and investigate the effects of insulin therapy and islet transplantation. After demonstrating the success of transplantation, further studies examined the feasibility of creating multiple grafts from a single donor and their long-term preservation. The totally pancreatectomized dog, treated with suboptimal insulin therapy was biochemically identical to human IDD and, when more appropriate doses of insulin were administered, metabolic improvements occurred without restoring normality. Islet cell autotransplants rendered such animals metabolically normal apart from persisting impairment of glucose tolerance. The isolation technique permitted the production of at least two recipient grafts and some success was achieved after graft cryopreservation. The experiments confirm the theoretical background to islet transplantation and demonstrate its applicability in a large animal model before allotransplantation.