Phenolic antioxidants-functionalized quaternized chitosan: Synthesis and antioxidant properties
Phenolic antioxidants-functionalized quaternized chitosan: Synthesis and antioxidant properties
复制标题
酚类抗氧化剂-功能化季铵化壳聚糖的合成及抗氧化性能
DOI：
10.1016/j.ijbiomac.2012.11.011
复制
发表时间：
2013-02-01
影响因子：
8.2
通讯作者：
Guo, Zhanyong
中科院分区：
文献类型：
--
作者：
Ren, Jianming;Li, Qing;Guo, Zhanyong
本工作合成了两种酚类抗氧化剂-功能化季铵化壳聚糖，以开发水溶性抗氧化剂-聚合物复合物。将没食子酸和咖啡酸分别与季铵化壳聚糖进行偶联，并分别考察了没食子酸季铵化壳聚糖和咖啡酸季铵化壳聚糖对羟自由基、超氧阴离子自由基和DPPH自由基的体外抗氧化性能。结果表明，没食子酸季铵化壳聚糖和咖啡酸季铵化壳聚糖的清除自由基能力明显高于壳聚糖和季铵化壳聚糖。在1000 μ g/mL浓度下，其清除率均大于90%。由于没食子酸季铵化壳聚糖和咖啡酸季铵化壳聚糖制备方便且具有更好的潜在活性，这些材料可能代表壳聚糖利用的一个有吸引力的新平台。(c)出版社：Elsevier B.V.
In this work, two kinds of phenolic antioxidants-functionalized quaternized chitosan were synthesized in order to develop aqueous soluble antioxidant-polymer conjugates. Quaternized chitosan conjugated with gallic acid or caffeic acid was carried out and the antioxidant properties of the products (namely gallic acid-quaternized chitosan and caffeic acid-quaternized chitosan) against hydroxyl-radical, superoxide-radical and DPPH-radical were evaluated in vitro, respectively. The scavenging activities of the obtained gallic acid-quaternized chitosan and caffeic acid-quaternized chitosan exhibit a remarkable improvement over those of either chitosan or quaternized chitosan. And the scavenging effect indices of the products were all higher than 90% at a concentration of 1000 mu g/mL. Because gallic acid-quaternized chitosan and caffeic acid-quaternized chitosan are convenient to prepare and possess improved potential activities, these materials may represent an attractive new platform for utilizations of chitosan. (c) 2012 Published by Elsevier B.V.