The maturation of the P1m component in response to voice from infancy to 3 years of age: A longitudinal study in young children
The maturation of the P1m component in response to voice from infancy to 3 years of age: A longitudinal study in young children
复制标题
从婴儿期到 3 岁，P1m 成分对声音的成熟：一项针对幼儿的纵向研究
DOI：
10.1002/brb3.1706
复制
发表时间：
2020
影响因子：
3.1
通讯作者：
Kikuchi Mitsuru
中科院分区：
文献类型：
--
作者：
Yoshimura Yuko;Hasegawa Chiaki;Ikeda Takashi;Saito Daisuke N.;Hiraishi Hirotoshi;Takahashi Tetsuya;Kumazaki Hirokazu;Kikuchi Mitsuru
前言在人类婴幼儿早期发育过程中，大脑皮层听觉处理功能的显著变化已有报道。在一般发育中的幼儿中，了解听觉皮质对人类声音反应的成熟轨迹，对于识别有神经发育障碍和语言障碍风险的儿童的声音处理异常至关重要。早前的脑电图学和脑磁图(MEG)研究已经报道了新生儿大脑听觉反应的一个早期显著的阳性成分。然而，尚不清楚1岁以下婴儿的这一显著成分是否对应于已报道的2岁以上幼儿的听觉P1m成分。方法为了验证这一假说，即0岁婴儿的早期显著阳性成分是我们之前在2岁以上儿童中报道的P1m的不成熟表现，我们进行了一项专注于这一早期成分的纵向脑磁图研究，并检查了从0岁开始三年的成熟变化。本研究发现3个月大婴儿的早期显著成分对应于2岁以上幼儿的听觉P1m成分，这与我们先前报道的与语言发育和/或自闭症谱系障碍有关的成分。结论我们的数据揭示了0-3岁儿童左右半球听觉诱发领域的发展。这些结果有助于阐明婴儿脑功能的发育。
IntroductionIn the early development of human infants and toddlers, remarkable changes in brain cortical function for auditory processing have been reported. Knowing the maturational trajectory of auditory cortex responses to human voice in typically developing young children is crucial for identifying voice processing abnormalities in children at risk for neurodevelopmental disorders and language impairment. An early prominent positive component in the cerebral auditory response in newborns has been reported in previous electroencephalography and magnetoencephalography (MEG) studies. However, it is not clear whether this prominent component in infants less than 1 year of age corresponds to the auditory P1m component that has been reported in young children over 2 years of age.MethodsTo test the hypothesis that the early prominent positive component in infants aged 0 years is an immature manifestation of P1m that we previously reported in children over 2 years of age, we performed a longitudinal MEG study that focused on this early component and examined the maturational changes over three years starting from age 0. Five infants participated in this 3‐year longitudinal study.ResultsThis research revealed that the early prominent component in infants aged 3 month corresponded to the auditory P1m component in young children over 2 years old, which we had previously reported to be related to language development and/or autism spectrum disorders.ConclusionOur data revealed the development of the auditory‐evoked field in the left and right hemispheres from 0‐ to 3‐year‐old children. These results contribute to the elucidation of the development of brain functions in infants.