Bioactive compounds from Psorothamnus junceus.
Bioactive compounds from Psorothamnus junceus.
复制标题
来自 Psorothamnus junceus 的生物活性化合物。
DOI：
10.1021/np990171l
复制
发表时间：
2000
影响因子：
5.1
通讯作者：
Chang,CJ
中科院分区：
文献类型：
--
作者：
Zhang,H;Li,X;Ashendel,CL;Chang,CJ
在从 Psorothamnus junceus 中寻找生物活性化合物的过程中，从茎皮的乙醇提取物中分离出了四种杂环化合物，即 Psorothamnone A (1)、Psorothamnone B (2)、dalrubone (3) 和 emorydone (4)。 Psorothamnones A (1) 和 B (2) 对蛋白激酶 C (PKC) 具有抑制活性，蛋白激酶 C 是参与细胞增殖和分化信号转导的关键酶。 Dalrubone (3) 和 emorydone (4) 对多种人类肿瘤细胞系表现出细胞毒性。
During a search for bioactive compounds fromPsorothamnus junceus, four heterocyclic compounds, psorothamnone A (1), psorothamnone B (2), dalrubone (3), and emorydone (4) were isolated from the ethanol extract of the stem bark. Psorothamnones A (1) and B (2) demonstrated inhibitory activity against protein kinase C (PKC), a key enzyme involved in the signal transduction of cell proliferation and differentiation. Dalrubone (3) and emorydone (4) showed cytotoxicity against several human tumor cell lines.