Should treatments for asthma be aimed at the airway smooth muscle?
Should treatments for asthma be aimed at the airway smooth muscle?
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DOI：
10.1586/17476348.1.2.209
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发表时间：
2007-10-01
影响因子：
3.9
通讯作者：
Chung, Kian Fan
中科院分区：
文献类型：
--
作者：
Chung, Kian Fan
气道平滑肌（ASM）细胞是哮喘患者气道壁的重要组成部分，因为其增加的收缩特性，在这种情况下似乎增强，并有助于气流阻塞和支气管高反应性。ASM细胞在哮喘中也是异常的，具有增加的某些趋化因子表达，具有增加的增殖速率、数量和大小。β-肾上腺素能激动剂和皮质类固醇是哮喘的两种最重要的治疗方法;其它使用的药物是白三烯受体拮抗剂和茶碱。β-肾上腺素能受体激动剂和皮质类固醇的联合治疗已成为中重度哮喘的治疗选择。β-肾上腺素能激动剂引起ASM细胞松弛，导致哮喘气流阻塞减少和症状急性缓解。皮质类固醇对ASM细胞也有直接作用。据推测，抗炎剂对ASM细胞的作用是这些药物治疗效果的最重要决定因素。靶向哮喘中的ASM细胞可能是哮喘治疗的焦点。活性剂向ASM细胞的特异性递送也可能是该策略的一部分。
The airway smooth muscle (ASM) cell is an important part of the airway wall of asthma patients because of its increased contractile properties, which appear to be enhanced in this condition and which contribute to airflow obstruction and bronchial hyper-responsiveness. ASM cells are also abnormal in asthma with increased expression of certain chemokines, with increased proliferation rate, numbers and size. beta-adrenergic agonists and corticosteroids are the two most important treatments for asthma; other drugs used are leukotriene receptor antagonists and theophylline. Combination therapy of beta-adrenergic agonists and corticosteroids has become the treatment of choice for moderate-to-severe asthma. beta-adrenergic agonists cause relaxation of ASM cells, leading to a decrease in airflow obstruction of asthma and acute relief of symptoms. Corticosteroids also have direct effects on ASM cells. It is postulated that the effect of anti-inflammatory agents on ASM cells is the most important determinant of the therapeutic effects of these agents. Targeting the ASM cell in asthma could be the focus of therapies for asthma. Specific delivery of active agents to ASM cells may also be part of this strategy.