Neuron-Restrictive Silencer Factor Limits Myocyte GαO Expression and Is Protective in Heart Failure Progression.
Neuron-Restrictive Silencer Factor Limits Myocyte GαO Expression and Is Protective in Heart Failure Progression.
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神经元限制性沉默因子限制肌细胞 GαO 表达并在心力衰竭进展中具有保护作用。
DOI：
10.1161/circresaha.121.320597
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发表时间：
2022
影响因子：
20.1
通讯作者：
Bers,DonaldM
中科院分区：
文献类型：
--
作者：
Sossalla,Samuel;Bers,DonaldM
许多信号通路参与了心肌肥厚、心力衰竭和心律失常的发生和发展。其中包括多种GPCRs(G蛋白偶联受体，如血管紧张素II)、激酶(PKA、PKC、CaMKII[钙调素依赖的蛋白激酶])、磷酸酶(如CaN[钙调神经磷酸酶])和转录修饰物(如NFATs、HDACs[组蛋白去乙酰酶]、MEF2和GATA4)，它们驱动结构重建和兴奋收缩耦合信号的改变，导致收缩/松弛和电生理改变。
Many signaling pathways have been implicated in the development and progression of cardiac hypertrophy to heart failure (HF) and arrhythmias. These include multiple GPCRs (G-protein–coupled receptors; eg, angiotensin II), kinases (PKA, PKC, CaMKII [Ca-calmodulin–dependent protein kinase]), phosphatases (eg, CaN [calcineurin]), and transcriptional modifiers (eg, NFATs, HDACs [histone deacetylases], MEF2, and GATA4) that drive structural remodeling and altered excitation-contraction coupling signaling to result in altered contraction/relaxation and electrophysiology.