Anti-cyclic citrullinated peptide antibodies in lung diseases associated with rheumatoid arthritis
Anti-cyclic citrullinated peptide antibodies in lung diseases associated with rheumatoid arthritis
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DOI：
10.1016/j.clinbiochem.2008.06.014
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发表时间：
2008-09-01
影响因子：
2.8
通讯作者：
Chida, Kingo
中科院分区：
文献类型：
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作者：
Inui, Naoki;Enomoto, Noriyuki;Chida, Kingo
目的：抗环瓜氨酸肽（抗CCP）抗体是类风湿关节炎（RA）的高度特异性标志物，可用于预测RA的发生和进展。然而，尚未完全确定抗CCP抗体是否与RA患者的肺部疾病相关。本研究旨在阐明抗CCP抗体与肺部疾病，特别是间质性肺病（ILD）和细支气管炎之间的关系。设计和方法：采用酶联免疫吸附试验，检测了18例RA患者血清中抗CCP抗体的存在。患有ILD和细支气管炎，并根据病理结果进行诊断。结果：RA患者血清中抗CCP抗体的检出率及水平与ILD及滤泡性细支气管炎的检出率及水平无显著性差异。结论：RA患者血清中抗CCP抗体的检出与肺部疾病无关。(C)2008年加拿大临床化学家协会。爱思唯尔公司出版All rights reserved.
Objective: Anti-cyclic citrullinated peptide (anti-CCP) antibodies are highly specific markers for rheumatoid arthritis (RA) and useful for predicting RA development and progression. However, it has not been fully determined whether anti-CCP antibodies are associated with pulmonary diseases in RA patients. In the present study, we aimed to elucidate the relationships between anti-CCP antibodies and pulmonary diseases, particularly interstitial lung disease (ILD) and bronchiolitis.Design and Methods: Using an enzyme-linked immunosorbent assay, the presence of serum anti-CCP antibodies was examined in 18 RA patients with ILD and bronchiolitis who were diagnosed based on pathologic findings. A further 36 RA subjects without any pulmonary diseases served as a reference population.Results: No significant differences were found for the prevalences and levels of anti-CCP antibodies between patients with and without ILD and follicular bronchiolitis.Conclusion: Detection of serum anti-CCP antibodies has no association with pulmonary diseases in RA patients. (C) 2008 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.