Degradation behaviour of block copolymers containing poly(lactic-glycolic acid) and poly(ethylene glycol) segments
Degradation behaviour of block copolymers containing poly(lactic-glycolic acid) and poly(ethylene glycol) segments
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DOI：
10.1016/0142-9612(95)00323-1
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发表时间：
1996-08-01
期刊：
影响因子：
14
通讯作者：
Deghenghi, R
中科院分区：
文献类型：
--
作者：
Penco, M;Marcioni, S;Deghenghi, R
在模拟生物体液的条件下，研究了一类含有聚（D，L-乳酸-乙醇酸）（PLGA）和聚乙二醇（PEG）链段的新型多嵌段共聚物的降解行为。新型PLGA-PEG多嵌段共聚物的溶解时间主要取决于其结构中存在的PEG链段的长度，即，基于重量/重量的PEG含量。在较高的PEG含量下，部分降解的PLGA片段通过连接的PEG片段被带入溶液中。在所有情况下，溶出速率均会随着受试样本总表面积的增加而降低。(C)1996年爱思唯尔科学有限公司
The degradation behaviour of a new class of multi-block copolymers containing poly(D,L-lactic-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG) segments was studied under conditions mimicking those found in biological fluids. The dissolution times of the new PLGA-PEG multi-block copolymers mainly depend on the length of the PEG segments present in their structure, i.e., on their PEG content on a weight/weight basis. At higher PEG contents, partially degraded PLGA segments are brought in solution by attached PEG segments. In all cases, the dissolution rates decrease by increasing the total surface area of the specimens tested. (C) 1996 Elsevier Science Limited