Evaluation of effects of multiple candidate genes (LEP, LEPR, MC4R, PIK3C3, and VRTN) on production traits in Duroc pigs
Evaluation of effects of multiple candidate genes (LEP, LEPR, MC4R, PIK3C3, and VRTN) on production traits in Duroc pigs
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DOI：
10.1111/asj.12134
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发表时间：
2014-03-01
影响因子：
2
通讯作者：
Tanaka, Kazuaki
中科院分区：
文献类型：
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作者：
Hirose, Kensuke;Ito, Tetsuya;Tanaka, Kazuaki
我们评估了纯杜洛克猪封闭核心猪群中五个候选基因座（LEP、LEPR、MC4R、PIK3C3 和 VRTN）遗传变异对四个生产性状（平均日增重 (ADG)、背膘厚度 (BFT)、腰眼肌面积 (EMA) 和肌内脂肪含量 (IMF)）的多重影响。 LEPR、MC4R和PIK3C3多态性对ADG和BFT具有显着的单基因效应。 ADG 和 BFT 的加性遗传方差（分别为 16.99% 和 22.51%）可以通过这三个位点的遗传效应来解释。本研究中未观察到LEP基因型与生产性状之间的相关性。尽管我们在眼肌区域检测到 LEPR 和 PIK3C3 之间存在轻微的上位相互作用，但对所有基因座对之间的任何性状均没有显着的上位效应。这些结果表明LEPR、MC4R、PIK3C3和VRTN可能独立影响生长速率和脂肪沉积。此外，同时考虑MC4R、LEPR、PIK3C3和VRTN基因型的影响时，预测各性状育种值的统计模型具有最低的Akaike信息准则值。这些结果表明 LEPR、MC4R、PIK3C3 和 VRTN 是准确预测杜洛克猪育种值的有用标记。
We evaluated multiple effects of genetic variations of five candidate loci (LEP,LEPR,MC4R,PIK3C3andVRTN) on four production traits (average daily weight gain (ADG); backfat thickness (BFT); loin eye muscle area (EMA); and intramuscular fat content (IMF)) in a closed nucleus herd of pure Duroc pigs. Polymorphisms inLEPR,MC4RandPIK3C3had significant single gene effects on ADG and BFT. The additive genetic variance in ADG and BFT (16.99% and 22.51%, respectively) was explained by genetic effects of these three loci. No correlations were observed between theLEPgenotype and production traits in this study. Although we detected marginally epistatic interactions betweenLEPRandPIK3C3on the eye muscle area, there were no significant epistatic effects on any traits among all loci pairs. These results suggest thatLEPR,MC4R,PIK3C3andVRTNmay independently influence growth rate and fat deposition. Furthermore, the statistical models for predicting the breeding values of each trait had the lowest Akaike's information criterion values when considering the effect of theMC4R,LEPR,PIK3C3andVRTNgenotype simultaneously. These results suggest thatLEPR,MC4R,PIK3C3andVRTNare useful markers for accurately predicting breeding values in Duroc pigs.