HIV-1 antigen-specific and -nonspecific B cell responses are sensitive to combination antiretroviral therapy.
HIV-1 antigen-specific and -nonspecific B cell responses are sensitive to combination antiretroviral therapy.
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DOI：
10.1084/jem.188.2.233
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发表时间：
1998-07-20
影响因子：
15.3
通讯作者：
Moore, J P
中科院分区：
文献类型：
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作者：
Morris, L;Binley, J M;Clas, B A;Bonhoeffer, S;Astill, T P;Kost, R;Hurley, A;Cao, Y;Markowitz, M;Ho, D D;Moore, J P
我们研究了联合抗病毒治疗如何影响与HIV-1感染相关的B细胞异常，即循环免疫球蛋白(Ig)G抗体分泌细胞(ASC)频率升高和高丙种球蛋白血症。在开始抗病毒治疗的几周内，在急性和慢性感染者中，IgG-ASC频率都明显下降，而在慢性感染期间经常出现的高丙种球蛋白血症更容易得到缓解。在抑制HIV-1复制的同时，这些减少也会持续下去。HIV-1抗原特异性B细胞反应也会受到治疗的影响，表现为循环中gp120特异性ASCs的迅速下降。在慢性感染者中，抗gp120滴度缓慢下降，而在迅速接受抗逆转录病毒治疗的急性感染者中，抗gp120滴度通常无法成熟。长期无进展者对HIV-1抗原有高滴度的抗体应答，但没有检测到gp120特异性的Ig-Asc，循环中总的Ig-A sC水平正常(或低于正常)。总体而言，我们得出结论，HIV-1感染导致B细胞过度活跃，这种多克隆激活对联合抗病毒治疗导致的病毒复制减少迅速做出反应。
We studied how combination antiviral therapy affects B cell abnormalities associated with HIV-1 infection, namely elevated circulating immunoglobulin (Ig)G antibody-secreting cell (ASC) frequencies and hypergammaglobulinemia. Within a few weeks of starting antiviral therapy, there is a marked decline in IgG-ASC frequency in both acutely and chronically infected people, whereas the hypergammaglobulinemia often present during chronic infection is more gradually resolved. These reductions are sustained while HIV-1 replication is suppressed. HIV-1 antigen–specific B cell responses are also affected by therapy, manifested by a rapid decline in circulating gp120-specific ASCs. Anti-gp120 titers slowly decrease in chronically infected individuals and usually fail to mature in acutely infected individuals who were promptly treated with antiretroviral therapy. Long-term nonprogressors have high titer antibody responses to HIV-1 antigens, but no detectable gp120-specific IgG-ASC, and normal (or subnormal) levels of total circulating IgG-ASC. Overall, we conclude that HIV-1 infection drives B cell hyperactivity, and that this polyclonal activation is rapidly responsive to decreases in viral replication caused by combination antiviral therapy.