Evidence for function of Ia molecules on gut epithelial cells in man.
Evidence for function of Ia molecules on gut epithelial cells in man.
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DOI：
10.1084/jem.166.5.1471
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发表时间：
1987-11-01
期刊：
影响因子：
--
通讯作者：
Shlien R
中科院分区：
文献类型：
--
作者：
Mayer L;Shlien R
使用新鲜分离的 Ia+ 肠道上皮细胞，我们已经能够证明这些细胞可以在免疫反应中充当辅助细胞。这些细胞可以作为自体和同种异体 MLR 的刺激剂。更重要的是，这些细胞能够吸收可溶性抗原、破伤风类毒素，对其进行加工，并将其呈递给破伤风引发的 T 细胞。这些功能似乎与表面 Ia 的存在有关，因为异源抗 Ia 抗体可以阻断这些作用。值得注意的是，当上皮细胞用作辅助细胞时，所刺激的 T 细胞亚群是 T8+、9.3-T 细胞。这些细胞在 MLR、T 细胞抗原反应和 PWM 诱导 B 细胞分化中充当有效的抗原非特异性抑制细胞。这些发现对局部肠道免疫反应具有重要意义，并可能有助于解释一些特征不明的粘膜免疫现象。
Using freshly isolated Ia+ gut epithelial cells we have been able to demonstrate that these cells can function as accessory cells in an immune response. The cells can act as stimulators in both autologous and allogeneic MLRs. More importantly, these cells are capable of taking up the soluble antigen, tetanus toxoid, processing it, and presenting it to tetanus-primed T cells. These functions appear to relate to the presence of surface Ia in that a hetero-anti-Ia antibody can block these effects. Noteworthy is the finding that the subpopulation of T cells stimulated when epithelial cells are used as accessory cells is the T8+, 9.3-T cell. These cells function as potent antigen-nonspecific suppressor cells in both MLR, T cell antigen responses, and induction of B cell differentiation by PWM. These findings have significant implications in local gut immune responses and may help explain several poorly characterized phenomena of mucosal immunity.