SPATIAL PATTERN OF RECEPTOR EXPRESSION IN THE OLFACTORY EPITHELIUM
SPATIAL PATTERN OF RECEPTOR EXPRESSION IN THE OLFACTORY EPITHELIUM
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DOI：
10.1073/pnas.89.19.8948
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发表时间：
1992-10-01
影响因子：
11.1
通讯作者：
HEINEMANN, SF
中科院分区：
文献类型：
--
作者：
NEF, P;HERMANSBORGMEYER, I;HEINEMANN, SF
一种基于PCR的策略，用于扩增参与小鼠嗅觉的假定受体，分离出七跨膜结构域受体超家族的一个成员（OR3）。在发育过程中，第一个表达OR3的细胞出现在胚胎第10天的端脑囊泡壁附近。OR3受体是唯一的表达在一个子集的嗅细胞，具有特征性的双边对称性在成人嗅上皮。这种受体及其特定的表达模式可能在气味编码中发挥功能性作用，或者在嗅觉系统的发育中发挥作用。
A PCR-based strategy for amplifying putative receptors involved in murine olfaction was employed to isolate a member (OR3) of the seven-transmembrane-domain receptor superfamily. During development, the first cells that express OR3 appear adjacent to the wall of the telencephalic vesicle at embryonic day 10. The OR3 receptor is uniquely expressed in a subset of olfactory cells that have a characteristic bilateral symmetry in the adult olfactory epithelium. This receptor and its specific pattern of expression may serve a functional role in odor coding or, alternatively, may play a role in the development of the olfactory system.