Endogenous opioids modulate ventilation and peak oxygen consumption in obese Zucker rats.
Endogenous opioids modulate ventilation and peak oxygen consumption in obese Zucker rats.
复制标题
内源性阿片类药物调节肥胖 Zucker 大鼠的通气和峰值耗氧量。
DOI：
10.1164/ajrccm.162.3.9909058
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Farkas,GA
中科院分区：
文献类型：
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作者：
Lee,SD;Nakano,H;Gosselin,LE;Krasney,JA;Schlenker,EH;Farkas,GA
内源性阿片样物质的水平在病态肥胖的人类和肥胖大鼠中增加。内源性阿片类物质是重要的神经调质，并参与广泛的功能，包括兴奋性控制。我们研究了8只6周龄和8只肥胖Zucker（Z）大鼠。我们评估了静息时和高碳酸血症挑战期间的每分钟通气量（V e），以及给予生理盐水（对照）、盐酸纳洛酮（NHCl）和甲碘纳洛酮（NM）后的峰值耗氧量（V o2 peak）。对瘦型动物给予NHC和NM对V stece和V steco 2 peak无影响。同样，NM不能改变6或16周龄肥胖大鼠的V stece和V steco 2峰值。在幼年肥胖大鼠中，NHCl显著（p <0.05）降低， 0.05）静息V速度增加（721 ± 154 [平均值± SD] ml/kg/min vs 937 ± 207 ml/kg/min，生理盐水vs NHCl）;静脉对4% CO2的反应（924 ± 110 ml/kg/min vs. 1，212 ± 172 ml/ kg/min）;对8% CO2的V stecein反应（1，233 ± 172 ml/kg/min vs 1，565 ± 327 ml/kg/min）;和V steco 2峰值（90.8 ± 9.6 ml/kg 0.75/min vs 98.3 ± 5.9 ml/kg 0.75/min）。然而，NHCl给药对16周龄肥胖大鼠的V steceor V steco 2峰值没有影响。因此，内源性阿片类物质通过特异性作用于位于中枢神经系统内的受体来调节年轻肥胖大鼠的静息通气、对CO2的呼吸反应和Vsteco 2峰值。一旦动物达到16周龄，这种调制消失。
Levels of endogenous opioids are increased in morbidly obese humans and obese rats. Endogenous opioids are important neuromodulators, and are involved in a wide range of functions including ventilatory control. We studied eight lean and eight obese Zucker (Z) rats at 6 and 16 wk of age. We assessed minute ventilation (V˙e) at rest and during hypercapnic challenges, as well as peak oxygen consumption (V˙o2peak) after the administration of saline (control), naloxone hydrochloride (NHCl), and naloxone methiodide (NM). Administration of NHCland NMto lean animals had no effect on V˙eand V˙o2peak. Similarly, NMfailed to alter V˙eand V˙o2peakin obese rats studied at 6 or 16 wk of age. In young obese rats, NHClsignificantly (p < 0.05) increased resting V˙e(721 ± 154 [mean ± SD] ml/kg/min versus 937 ± 207 ml/kg/min, saline versus NHCl, respectively); Vein response to 4% CO2(924 ± 110 ml/kg/min versus 1,212 ± 172 ml/ kg/min); V˙ein response to 8% CO2(1,233 ± 172 ml/kg/min versus 1,565 ± 327 ml/kg/min); and V˙o2peak(90.8 ± 9.6 ml/kg0.75/min versus 98.3 ± 5.9 ml/kg0.75/min). However, NHCladministration had no effect on V˙eor V˙o2peakin obese rats retested at 16 wk of age. Thus, endogenous opioids modulate resting ventilation, ventilatory responsiveness to CO2, and V˙o2peakin young obese rats by acting specifically on receptors located within the central nervous system. This modulation disappears once the animals reach 16 wk of age.