Cat scratch disease: analysis of 130 seropositive cases
Cat scratch disease: analysis of 130 seropositive cases
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猫抓病：130例血清阳性病例分析
DOI：
10.1007/s10156-002-0194-6
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发表时间：
2002
影响因子：
2.2
通讯作者：
K. Sasaki
中科院分区：
文献类型：
--
作者：
Kyoko Murakami;M. Tsukahara;H. Tsuneoka;Hidechika Iino;C. Ishida;Kumiko Tsujino;A. Umeda;T. Furuya;S. Kawauchi;K. Sasaki
摘要为了明确猫抓病（CSD）的临床表现，我们对130例血清阳性的CSD患者进行了评估。患者年龄1 ~ 68岁；18岁以下103例（79.2%）。CSD主要发生在秋季和冬季。110例（84.6%）有局部淋巴结病变，最常见的部位是颈部（33%）、腋窝（27%）和腹股沟（18%）。100例患者（77%）有一般症状，如发烧、头痛和不适。CSD的临床表现广泛，从典型或经典的CSD，并伴有局部淋巴结病变，到不典型或全身性CSD。130例中，典型CSD 103例（79.2%），不典型CSD 27例（20.8%）。不典型CSD的常见病例为不明原因发热（37.0%）、神经视网膜炎（22.2%）、脑病（14.8%）、肝脾肉芽肿（11.1%）和Parinaud眼腺综合征（7.4%）。在本研究的130例病例中，有27例（20.8%）出现不明原因发热或持续发热超过14天。27例中有11例没有淋巴结病变。我们的研究结果表明，CSD在日本不是一种罕见的疾病。采用间接荧光抗体（IFA）检测巴尔通体，可为CSD提供及时的诊断和适当的治疗。
Abstract To clarify the clinical manifestations of cat scratch disease (CSD), we evaluated a total of 130 seropositive patients with CSD. The patients' ages ranged from 1 to 68 years; 103 (79.2%) were under 18 years of age. CSD occurred predominantly in the fall and winter months. Regional lymphadenopathy was noted in 110 (84.6%) of the cases, and the most common sites were the neck (33%), axillary (27%), and inguinal (18%) regions. One hundred of the patients (77%) had general symptoms, such as fever, headache, and malaise. The clinical manifestations of CSD showed a wide spectrum from typical or classical CSD, with regional lymphadenopathy, to atypical or systemic CSD. Of the 130 cases, 103 (79.2%) were typical CSD and 27 (20.8%) were atypical CSD. Atypical cases of CSD were commonly reported as fever of unknown origin (37.0%), neuroretinitis (22.2%), encehalopathy (14.8%), hepatosplenic granuloma (11.1%), and Parinaud's oculoglandular syndrome (7.4%). Fever of unknown origin or prolonged fever lasting more than 14 days was evident in 27 (20.8%) of the 130 cases in this study. Eleven of the 27 cases lacked lymphadenopathy. Our findings suggest that CSD is not a rare disease in Japan. The indirect fluorescent antibody (IFA) test to detect Bartonella species may provide a prompt diagnosis of CSD and facilitate appropriate therapy.